Synthesis and antiviral properties of new derivatives of 2-(alkylsulfanyl)-6-[1-(2,6-difluorophenyl)cyclopropyl]-5-methylpyrimidin-4(3H)-one


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Based on 2-(2,6-difluorophenyl)acetonitrile a synthesis was performed of new bioisosteric prochiral analogs of anti-HIV-1 active derivatives of 2-alkoxy-6-benzylpyrimidin-4(3Н)-one that we had previously obtained. The study using infected and nonifected strains of cells MT-4 made it possible to find in all prepared compounds a high anti-HIV activity whereas the cytotoxicity of the substances depended strongly on the structure of the alkylsulfanyl fragment of the molecule.

作者简介

I. Novakov

Volgograd State Technical University

Email: asbabyshkin@gmail.com
俄罗斯联邦, pr. Lenina 28, Volgograd, 400005

A. Yablokov

Volgograd State Technical University

Email: asbabyshkin@gmail.com
俄罗斯联邦, pr. Lenina 28, Volgograd, 400005

B. Orlinson

Volgograd State Technical University

Email: asbabyshkin@gmail.com
俄罗斯联邦, pr. Lenina 28, Volgograd, 400005

M. Navrotskii

Volgograd State Technical University

Email: asbabyshkin@gmail.com
俄罗斯联邦, pr. Lenina 28, Volgograd, 400005

I. Kirillov

Volgograd State Technical University

Email: asbabyshkin@gmail.com
俄罗斯联邦, pr. Lenina 28, Volgograd, 400005

A. Vernigora

Volgograd State Technical University

Email: asbabyshkin@gmail.com
俄罗斯联邦, pr. Lenina 28, Volgograd, 400005

A. Babushkin

Volgograd State Technical University

编辑信件的主要联系方式.
Email: asbabyshkin@gmail.com
俄罗斯联邦, pr. Lenina 28, Volgograd, 400005

V. Kachala

Zelinskii Institute of Organic Chemistry

Email: asbabyshkin@gmail.com
俄罗斯联邦, Moscow

D. Schols

Rega Institute for Medical Research

Email: asbabyshkin@gmail.com
比利时, Leuven

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