Synthesis and antiviral properties of new derivatives of 2-(alkylsulfanyl)-6-[1-(2,6-difluorophenyl)cyclopropyl]-5-methylpyrimidin-4(3H)-one
- 作者: Novakov I.A.1, Yablokov A.S.1, Orlinson B.S.1, Navrotskii M.B.1, Kirillov I.A.1, Vernigora A.A.1, Babushkin A.S.1, Kachala V.V.2, Schols D.3
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隶属关系:
- Volgograd State Technical University
- Zelinskii Institute of Organic Chemistry
- Rega Institute for Medical Research
- 期: 卷 52, 编号 8 (2016)
- 页面: 1188-1193
- 栏目: Article
- URL: https://journals.rcsi.science/1070-4280/article/view/214856
- DOI: https://doi.org/10.1134/S1070428016080169
- ID: 214856
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详细
Based on 2-(2,6-difluorophenyl)acetonitrile a synthesis was performed of new bioisosteric prochiral analogs of anti-HIV-1 active derivatives of 2-alkoxy-6-benzylpyrimidin-4(3Н)-one that we had previously obtained. The study using infected and nonifected strains of cells MT-4 made it possible to find in all prepared compounds a high anti-HIV activity whereas the cytotoxicity of the substances depended strongly on the structure of the alkylsulfanyl fragment of the molecule.
作者简介
I. Novakov
Volgograd State Technical University
Email: asbabyshkin@gmail.com
俄罗斯联邦, pr. Lenina 28, Volgograd, 400005
A. Yablokov
Volgograd State Technical University
Email: asbabyshkin@gmail.com
俄罗斯联邦, pr. Lenina 28, Volgograd, 400005
B. Orlinson
Volgograd State Technical University
Email: asbabyshkin@gmail.com
俄罗斯联邦, pr. Lenina 28, Volgograd, 400005
M. Navrotskii
Volgograd State Technical University
Email: asbabyshkin@gmail.com
俄罗斯联邦, pr. Lenina 28, Volgograd, 400005
I. Kirillov
Volgograd State Technical University
Email: asbabyshkin@gmail.com
俄罗斯联邦, pr. Lenina 28, Volgograd, 400005
A. Vernigora
Volgograd State Technical University
Email: asbabyshkin@gmail.com
俄罗斯联邦, pr. Lenina 28, Volgograd, 400005
A. Babushkin
Volgograd State Technical University
编辑信件的主要联系方式.
Email: asbabyshkin@gmail.com
俄罗斯联邦, pr. Lenina 28, Volgograd, 400005
V. Kachala
Zelinskii Institute of Organic Chemistry
Email: asbabyshkin@gmail.com
俄罗斯联邦, Moscow
D. Schols
Rega Institute for Medical Research
Email: asbabyshkin@gmail.com
比利时, Leuven
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