New facilities of Biginelli reaction. Synthesis of methyl 6-aryl-5-benzoyl-4-methoxy-2-oxohexahydropyrimidine-4-carboxylates


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Three-component reaction of methyl benzoylpyruvate, aromatic aldehyde, and urea in methanol in the presence of sodium bisulfate stops at the stage of the formation of nondehydrated product with a methylated tertiary hydroxy group and results in methyl 6-aryl-5-benzoyl-4-methoxy-2-oxohexahydropyrimidine-4-carboxylates.

作者简介

V. Gein

Perm State Pharmaceutical Academy of the Health Protection Ministry of the Russian Federation

编辑信件的主要联系方式.
Email: geinvl48@mail.ru
俄罗斯联邦, ul. Polevaya 2, Perm, 614990

E. Gorgopina

Perm State Pharmaceutical Academy of the Health Protection Ministry of the Russian Federation

Email: geinvl48@mail.ru
俄罗斯联邦, ul. Polevaya 2, Perm, 614990

T. Zamaraeva

Perm State Pharmaceutical Academy of the Health Protection Ministry of the Russian Federation

Email: geinvl48@mail.ru
俄罗斯联邦, ul. Polevaya 2, Perm, 614990

M. Dmitriev

Perm State National Research University

Email: geinvl48@mail.ru
俄罗斯联邦, Perm, 614990

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