Email this article Solvent-Free Synthesis, ADME Prediction, and Evaluation of Antibacterial Activity of Novel Sulfonamide Derivatives
- Authors: Rafiee Pour Z.1, Nazifi S.M.2, Afshari Safavi A.3, Nazifi Z.S.1, Massah A.R.1,4
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Affiliations:
- Department of Chemistry, Shahreza Branch
- Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences
- Student Research Committee, School of Health
- Razi Chemistry Research Center, Shahreza Branch
- Issue: Vol 55, No 6 (2019)
- Pages: 852-859
- Section: Review
- URL: https://journals.rcsi.science/1070-4280/article/view/220770
- DOI: https://doi.org/10.1134/S1070428019060162
- ID: 220770
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Abstract
A series of novel sulfonamides containing a 2-amino-1,3-thiazole fragment have been synthesized using a simple and efficient method under solvent-free conditions. The obtained N-(4-sulfamoyl-1,3-thiazol-2-yl)-4-nitrobenzamides were evaluated for their antibacterial activity against S. aureus and E. coli, and in silico ADME prediction was performed to find biological behavior.
About the authors
Z. Rafiee Pour
Department of Chemistry, Shahreza Branch
Email: massah@iaush.ac.ir
Iran, Islamic Republic of, Shahreza, Isfahan
S. M. R. Nazifi
Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences
Email: massah@iaush.ac.ir
Iran, Islamic Republic of, Isfahan
A. Afshari Safavi
Student Research Committee, School of Health
Email: massah@iaush.ac.ir
Iran, Islamic Republic of, Isfahan
Z. S. Nazifi
Department of Chemistry, Shahreza Branch
Email: massah@iaush.ac.ir
Iran, Islamic Republic of, Shahreza, Isfahan
A. R. Massah
Department of Chemistry, Shahreza Branch; Razi Chemistry Research Center, Shahreza Branch
Author for correspondence.
Email: massah@iaush.ac.ir
Iran, Islamic Republic of, Shahreza, Isfahan; Shahreza, Isfahan
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