Recognition and Sensing of Guanidine-containing Biomolecules in Aqueous Medium

Abstract

A dicarboxylate-based fluorescent receptor has been synthesized for the recognition of the guanidinium ion and guanidine-containing biomolecules in aqueous medium to address the issue of biomolecular interaction. The acyclic receptor binds to guests in a 1: 2 mode due to the flexibility of its binding motifs. The host-guest binding behavior was studied by means of UV and fluorescence titration. The binding of the host with the guanidinium ion was found to be stronger than with the other guanidine-containing guests.