Alkylation of 3-tert-Butylpyrimido[4′,5′:3,4]pyrazolo[5,1-c]-[1,2,4]triazine-4,10(1H,9H)-diones and -dithiones
- Авторы: Mironovich L.M.1, Ivanov S.M.2, Daeva E.D.2
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Учреждения:
- Southwest State University
- Zelinskii Institute of Organic Chemistry
- Выпуск: Том 55, № 7 (2019)
- Страницы: 958-963
- Раздел: Article
- URL: https://journals.rcsi.science/1070-4280/article/view/220848
- DOI: https://doi.org/10.1134/S1070428019070066
- ID: 220848
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Аннотация
The condensation of 7-amino-1-benzyl-3-tert-butyl-4-oxo-1,4-dihydropyrazolo[5,1-c][1,2,4]triazine-8-carbonitrile with formic acid afforded 1-benzyl-3-tert-butylpyrimido[4′,5′:3,4]pyrazolo[5,1-c][1,2,4]-triazine-4,10(1H,9H)-dione which was also synthesized by alkylation of 3-tert-butylpyrimido[4′,5′: 3,4]pyrazolo[5,1-c][1,2,4]triazine-4,10(1H,9H)-dione with benzyl chloride. The reactions of 1-benzyl- and 1-butyl-3-tert-butylpyrimido[4′,5′: 3,4]pyrazolo[5,1-c][1,2,4]triazine-4,10(1H,9H)-diones with butyl bromide and benzyl chloride, respectively, under harsh conditions gave substitution products at the N9 atom, the corresponding 1-benzyl-9-butyl and 9-benzyl-1-butyl derivatives. The alkylation of 3-tert-butyl pyrimido[4′,5′: 3,4]-pyrazolo[5,1-c][1,2,4]triazine-4,10(1H,9H)-dithione and its 8-methyl derivative in alkaline medium led to the formation of alkyl derivatives at the sulfur atom in the 10-position.
Об авторах
L. Mironovich
Southwest State University
Автор, ответственный за переписку.
Email: lm.myronovych@mail.ru
Россия, Kursk
S. Ivanov
Zelinskii Institute of Organic Chemistry
Email: lm.myronovych@mail.ru
Россия, Moscow
E. Daeva
Zelinskii Institute of Organic Chemistry
Email: lm.myronovych@mail.ru
Россия, Moscow
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