Synthesis of an Acyclic Precursor to Epothilone D Analog. Aldol Condensation of (1R)-1-(1,3-Dithiolan-2-yl)-1-(methoxymethoxy)- 2,2-dimethylpentan-3-one with C6‒C21 and C6‒C9 Aldehyde Segments


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The synthesis of acyclic precursors to epothilone D analogs has been explored. Optimal conditions have been found for enolization of (1R)-1-(1,3-dithiolan-2-yl)-1-(methoxymethoxy)-2,2-dimethylpentan-3-one and its aldol condensation with C6‒C21 and C6‒C9 aldehydes.

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R. Valeev

Ufa Institute of Chemistry, Ufa Federal Research Center

编辑信件的主要联系方式.
Email: rusl0@yandex.ru
俄罗斯联邦, pr. Oktyabrya 71, Ufa, Bashkortostan, 450054

G. Sunagatullina

Ufa Institute of Chemistry, Ufa Federal Research Center

Email: rusl0@yandex.ru
俄罗斯联邦, pr. Oktyabrya 71, Ufa, Bashkortostan, 450054

V. Loza

Ufa Institute of Chemistry, Ufa Federal Research Center

Email: rusl0@yandex.ru
俄罗斯联邦, pr. Oktyabrya 71, Ufa, Bashkortostan, 450054

M. Miftakhov

Ufa Institute of Chemistry, Ufa Federal Research Center

Email: rusl0@yandex.ru
俄罗斯联邦, pr. Oktyabrya 71, Ufa, Bashkortostan, 450054

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