电邮这篇文章 Synthesis of Immunoactive Tris(2-hydroxyethyl)ammonium 1-R-Indol-3-ylsulfanyl(sulfonyl)acetates
- 作者: Adamovich S.N.1,2, Mirskova A.N.1,2
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隶属关系:
- Favorsky Institute of Chemistry, Siberian Branch
- Irkutsk Scientific Center, Siberian Branch
- 期: 卷 91, 编号 3 (2018)
- 页面: 469-472
- 栏目: Specific Technological Solutions
- URL: https://journals.rcsi.science/1070-4272/article/view/215745
- DOI: https://doi.org/10.1134/S1070427218030205
- ID: 215745
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详细
Difficultly accessible 1-R-indol-3-ylsulfanyl(sulfonyl)acetic acids 1-R-IndYCH2CO2H (R = H, Me, Bn; Y = S, SO2) 1a–Id were prepared. Their reaction with tris(2-hydroxyethyl)amine yielded tris(2-hydroxyethyl) ammonium 1-R-indol-3-ylsulfanyl(sulfonyl)aceetates (protatranes) 2a–2d. The immunoactive properties of 2a–2d were studied. Protatranes 2a, 2c, and 2d proved to be effective immunosuppressive agents (up to 99.5% inhibition of mice splenocyte proliferation in vitro).
作者简介
S. Adamovich
Favorsky Institute of Chemistry, Siberian Branch; Irkutsk Scientific Center, Siberian Branch
Email: mir@irioch.irk.ru
俄罗斯联邦, ul. Favorskogo 1, Irkutsk, 664033; ul. Lermontova 134, Irkutsk, 664033
A. Mirskova
Favorsky Institute of Chemistry, Siberian Branch; Irkutsk Scientific Center, Siberian Branch
编辑信件的主要联系方式.
Email: mir@irioch.irk.ru
俄罗斯联邦, ul. Favorskogo 1, Irkutsk, 664033; ul. Lermontova 134, Irkutsk, 664033
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