Impacts of Chemical Variables on the Encapsulated Corticoids in Poly-ε-caprolactone Nanoparticles and Statistical Biological Analysis
- Autores: Amiri Dehkharghani R.1, Zandi Doust M.1, Tavassoti Kheiri M.2, Hossein Shahi H.1
-
Afiliações:
- Department of Chemistry, Central Tehran Branch
- Department of Influenza Unit
- Edição: Volume 91, Nº 7 (2018)
- Páginas: 1165-1171
- Seção: Macromolecular Compounds and Polymeric Materials
- URL: https://journals.rcsi.science/1070-4272/article/view/215959
- DOI: https://doi.org/10.1134/S1070427218070157
- ID: 215959
Citar
Resumo
The goal of this research is to evaluate the impact of different parameters on corticosteroids entrapment in biocompatible poly-ε-caprolactone nanoparticles. These findings provide better insight on the designing carriers for drugs. Nanocapsules were synthesized by interfacial deposition and their morphology was determined by SEM. Drug entrapment efficiency and particle size distribution were assayed by HPLC and DLS, respectively. The samples were assessed for cytotoxicity using MTT reduction assay. The anti-inflammatory effect of the formulated drug was determined by induction of inflammation in treated as well as native laboratory animals. Statistical analysis of the data was performed using SPSS 18.0.
Palavras-chave
Sobre autores
R. Amiri Dehkharghani
Department of Chemistry, Central Tehran Branch
Autor responsável pela correspondência
Email: rahebeha@gmail.com
Irã, Tehran
M. Zandi Doust
Department of Chemistry, Central Tehran Branch
Email: rahebeha@gmail.com
Irã, Tehran
M. Tavassoti Kheiri
Department of Influenza Unit
Email: rahebeha@gmail.com
Irã, Tehran
H. Hossein Shahi
Department of Chemistry, Central Tehran Branch
Email: rahebeha@gmail.com
Irã, Tehran
Arquivos suplementares
