Encapsulation of Niacin into Nanocontainers on Ion Exchanger Matrices

Abstract

Ion-exchange encapsulation of niacin into nanocontainers on polymer matrices was performed. Dowex-50 cation-exchange resin, sulfonated polymer based on metacyclophanoctol, zirconium phosphate, and Dowex-1 strongly basic anion-exchange resin were used as matrices. The niacin encapsulation was proved by the experimental data on the material balance of niacin in the equilibrium solution and polymer and was confirmed by solid-state ¹³С and ¹⁵N NMR spectroscopy of the polymers. Niacin in the nanocontainers occurs in the form of cations or anions. The niacin content of the nanocontainers on Dowex-1 and Dowex-50 matrices is 33 and 64% relative to the polymer weight. Niacin was released from the nanocontainers by elution with aqueous HCl and NaCl solutions simulating the electrolyte composition of the human gastrointestinal tract.