DNA Binding Studies and Evaluation of Electrochemical Parameters of New Tri-and Di-Organotin(IV) Complexes of 4-(1H-Indol-3-yl)butanoic Acid
- Authors: Khalid S.1, Shaheen F.2, Ali S.1
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Affiliations:
- Department of Chemistry
- Department of Chemistry, Faculty of Sciences
- Issue: Vol 88, No 8 (2018)
- Pages: 1720-1725
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222380
- DOI: https://doi.org/10.1134/S1070363218080261
- ID: 222380
Cite item
Abstract
New triorganotin(IV) [R3SnL where R = Me (1), Bu (2), Ph (3)] and diorganotin(IV) [R2SnL2, where R = Me (4), Bu (5), Ph (6)] derivatives of 4-(1H-indol-3-yl)butanoic acid (HL) were prepared and characterized by FT-IR and 1H and 13C NMR spectroscopy. Interaction between DNA and selected compounds was studied by UV-Vis spectroscopy and viscometry. The binding constants calculated on the basis of the accumulated data reveal the following order of binding strength: compound 2 > 1 > 5 > 4. Electrochemical parameters such as diffusion coefficient and charge transfer coefficient are evaluated with cyclic voltammetry. The results demonstrate that diorganotin(IV) complexes are characterized by higher diffusion coefficient than triorganotin(IV) analogues. In case of triorganotin(IV) complexes, the lower coordination number allows a solvent to interact with Sn(IV) center and hence decreases the rate of diffusion.
Keywords
About the authors
S. Khalid
Department of Chemistry
Email: farzanaqau2013@gmail.com
Pakistan, Islamabad, 45320
F. Shaheen
Department of Chemistry, Faculty of Sciences
Author for correspondence.
Email: farzanaqau2013@gmail.com
Pakistan, Islamabad, 44000
S. Ali
Department of Chemistry
Email: farzanaqau2013@gmail.com
Pakistan, Islamabad, 45320
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