Crystal Structure and Biological Activity of Two Novel Coordination Polymers as Anti-Gastric Cancer Agents

Resumo

Two new coordination polymers, namely [Cd₂(Mna)₂(Phen)]_n (I) (H₂Mna = 6-mercaptonicotinic acid, Phen = 1,10-phenanthroline) and {[Mn(Ddca)(Phen)](H₂O)}_n (II) (H₂Ddca = 6,6'-dithiodinicotinic acid), have been obtained by using H₂Ddca and Phen as the organic building blocks under different reaction conditions. The structures of these complexes have been successfully determined by single crystal X-ray diffraction (CIF files CCDC nos. 1811835 (I), 1811836 (II)). In addition, in vitro antitumor activity of compounds I and II on four human gastric cancer cells (MGC-803, BGC-823, SGC-7901 and AGS) was further determined and the results show that the two compounds showed promising activity.