Copper complexes with 4(3H)-quinazolinone: Thermal gravimetric analysis and anticancer activity of [Cu(L)2(H2O)2(NO3)2], [Cu(L–)(NO3)]n, and [Cu(L)2(H2O)2(Cl)2]

Resumo

The title complexes [Cu(L)₂(H₂O)₂(NO₃)₂] (I), [Cu(L^–)(NO₃)]_n (II), and [Cu(L)₂(H₂O)₂(Cl)₂] (III), where L = 4(3H)-quinazolinone, had been synthesized and characterized by elemental analysis, and single crystal X-ray diffraction analysis (CIF files CCDC nos. 1409899 (I), 1409901 (II), 1409900 (III)). The results show that complex I belongs to the triclinic system, space group P\(\bar 1\); complex II belongs to the orthorhombic system, space group Pbca; complex III belongs to the monoclinic system, space group P2₁/c. TG curves show that complex II is more stable than complex I and complex III. Anticancer activity of the complex I was 25.92, 9.70, 13.58 and 18.56 μg mL^–1 against the human cancer cells 7404, A549, HepG2 and NCI-H1650, respectively.