Email this article Cobalt(III) complexes with biguanide derivatives: Synthesis, structures, and antiviral activity
- Authors: Kirin V.P.1,2, Demkin A.G.2, Smolentsev A.I.1, Il’icheva T.N.2, Maksakov V.A.1,2
-
Affiliations:
- Nikolaev Institute of Inorganic Chemistry, Siberian Branch
- Novosibirsk State University
- Issue: Vol 42, No 4 (2016)
- Pages: 260-266
- Section: Article
- URL: https://journals.rcsi.science/1070-3284/article/view/213392
- DOI: https://doi.org/10.1134/S1070328416040023
- ID: 213392
Cite item
Open Access
Access granted
Subscription Access
Abstract
Three Co(III) complexes with biguanide derivatives [Co(NH2C(=NH)NHC(=NH)NR1R2)3]Cl3 (R1R2 = Me2 (I), Et2 (II), and HsBu (III)) were obtained and characterized by elemental analysis, IR spectroscopy, and electronic absorption spectroscopy. Structure III was confirmed by X-ray diffraction (CIF file CCDC no. 1401783). Complexes I–III and [M(SC(NH2)2)4]Cl2 (M = Pd, Pt, and [Co(En)3]Cl3) were tested for in vitro antiviral activity against the A/California/07/09 (H1N1pdm09) influenza virus. The best results were achieved with complex III and both thiourea complexes.
About the authors
V. P. Kirin
Nikolaev Institute of Inorganic Chemistry, Siberian Branch; Novosibirsk State University
Email: maksakov@niic.nsc.ru
Russian Federation, Novosibirsk; Novosibirsk
A. G. Demkin
Novosibirsk State University
Email: maksakov@niic.nsc.ru
Russian Federation, Novosibirsk
A. I. Smolentsev
Nikolaev Institute of Inorganic Chemistry, Siberian Branch
Email: maksakov@niic.nsc.ru
Russian Federation, Novosibirsk
T. N. Il’icheva
Novosibirsk State University
Email: maksakov@niic.nsc.ru
Russian Federation, Novosibirsk
V. A. Maksakov
Nikolaev Institute of Inorganic Chemistry, Siberian Branch; Novosibirsk State University
Author for correspondence.
Email: maksakov@niic.nsc.ru
Russian Federation, Novosibirsk; Novosibirsk
Supplementary files
