Radiolabeling, Preparation, and Bioevaluation of 99mTc-Azathioprine as a Potential Targeting Agent for Solid Tumor Imaging
- Авторы: Sanad M.H.1, Marzook F.1, Saleh G.M.2, Farag A.B.3, Talaat H.M.1
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Учреждения:
- Labeled Compounds Department, Hot Laboratories Center
- Health Radiation Research Department (Radio diagnosis Unit), National Center for Radiation Research and Technology
- Pharmaceutical Chemistry Department, Faculty of Pharmacy
- Выпуск: Том 61, № 4 (2019)
- Страницы: 478-482
- Раздел: Article
- URL: https://journals.rcsi.science/1066-3622/article/view/225253
- DOI: https://doi.org/10.1134/S106636221904012X
- ID: 225253
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Аннотация
Azathioprine, an antitumor agent, was labeled with 99mTc using stannous chloride dihydrate as a reducing agent. Factors such as the amounts of the reducing agent and substrate, pH, and reaction temperature and time were systematically studied to determine the optimum conditions, under which the 95% radiochemical yield was achieved. Biodistribution studies demonstrate the suitability of 99mTc-azathioprine as a novel tracer for tumor imaging. It shows high selectivity to high-replicating solid tumors.
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Об авторах
M. Sanad
Labeled Compounds Department, Hot Laboratories Center
Автор, ответственный за переписку.
Email: drsanad74@gmail.com
Египет, Cairo
F. Marzook
Labeled Compounds Department, Hot Laboratories Center
Email: drsanad74@gmail.com
Египет, Cairo
G. Saleh
Health Radiation Research Department (Radio diagnosis Unit), National Center for Radiation Research and Technology
Email: drsanad74@gmail.com
Египет, Cairo
A. Farag
Pharmaceutical Chemistry Department, Faculty of Pharmacy
Email: drsanad74@gmail.com
Египет, Giza
H. Talaat
Labeled Compounds Department, Hot Laboratories Center
Email: drsanad74@gmail.com
Египет, Cairo
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