Preparation and biological evaluation of 99mTc-timonacic acid as a new complex for hepatobiliary imaging
- Авторы: Sanad M.1, El-Tawoosy M.1, Ibrahim I.1
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Учреждения:
- Labeled Compounds Department, Radioisotopes Production and Sources Division
- Выпуск: Том 59, № 1 (2017)
- Страницы: 92-97
- Раздел: Article
- URL: https://journals.rcsi.science/1066-3622/article/view/223753
- DOI: https://doi.org/10.1134/S106636221701012X
- ID: 223753
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Аннотация
Timonacic acid (TCA) was successfully labeled with 99mTc. The influence exerted on the reaction by the substrate and reducing agent concentrations, pH of the reaction mixture, and reaction time was examined, and in vitro stability of 99mTc-TCA was evaluated. The maximum labeling yield was 98.5 ± 0.6%. The complex was stable throughout the working period (6 h). A study of in-vivo biodistribution in mice showed that the maximum uptake of 99mTc-TCA in the liver was 22.3 ± 0.3% of the injected activity per gram of the tissue or organ (% ID/g) at 30 min post injection. The clearance from the mice appeared to proceed via the circulation mainly through the kidneys and urine (approximately 56% of the injected dose at 1 h after injection). The liver uptake of 99mTc-TCA is higher than that of 99mTc-UDCA (ursodeoxycholic acid); therefore, 99mTc-TCA shows more promise for liver SPECT.
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Об авторах
M. Sanad
Labeled Compounds Department, Radioisotopes Production and Sources Division
Автор, ответственный за переписку.
Email: msanad74@yahoo.com
Египет, Cairo
M. El-Tawoosy
Labeled Compounds Department, Radioisotopes Production and Sources Division
Email: msanad74@yahoo.com
Египет, Cairo
I. Ibrahim
Labeled Compounds Department, Radioisotopes Production and Sources Division
Email: msanad74@yahoo.com
Египет, Cairo