Enviar artigo por via de e-mail Synthesis of a carbon-14 analog of 8-chloro-11- (4-methyl-1-piperazinyl)-11-[14C]-5H-dibenzo[b,e][1,4]diazepine (clozapine) using microwave irradiation
- Autores: Saadatjoo N.1, Javaheri M.1,2, Saemian N.2, Amini M.3
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Afiliações:
- Department of Organic Chemistry, Faculty of Chemistry
- Applied Radiation Research School
- Department of Medicinal Chemistry, Faculty of Pharmacy and Drug Design and Development Research Center
- Edição: Volume 58, Nº 4 (2016)
- Páginas: 423-425
- Seção: Article
- URL: https://journals.rcsi.science/1066-3622/article/view/223458
- DOI: https://doi.org/10.1134/S1066362216040123
- ID: 223458
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Resumo
8-Chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine labeled with 14C in 11-position was synthesized in four steps from [carboxyl-14C]anthranilic acid using microwave irradiation with good overall radiochemical yield.
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Sobre autores
N. Saadatjoo
Department of Organic Chemistry, Faculty of Chemistry
Autor responsável pela correspondência
Email: nsaadatjoo@semnan.ac.ir
Irã, Semnan
M. Javaheri
Department of Organic Chemistry, Faculty of Chemistry; Applied Radiation Research School
Email: nsaadatjoo@semnan.ac.ir
Irã, Semnan; Semnan
N. Saemian
Applied Radiation Research School
Email: nsaadatjoo@semnan.ac.ir
Irã, Semnan
M. Amini
Department of Medicinal Chemistry, Faculty of Pharmacy and Drug Design and Development Research Center
Email: nsaadatjoo@semnan.ac.ir
Irã, Tehran, 14176
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