Preparation of 188Re-Labetalol as a β1-Adrenoceptor for Use in Nuclear Medicine
- Авторлар: Marzook F.A.1, Ramadan H.E.2, Talaat H.M.1
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Мекемелер:
- Labeled Compounds Department, Hot Laboratories Center
- Radioactive Isotopes and Generator Department, Hot Laboratories Center
- Шығарылым: Том 61, № 2 (2019)
- Беттер: 238-243
- Бөлім: Article
- URL: https://journals.rcsi.science/1066-3622/article/view/225110
- DOI: https://doi.org/10.1134/S1066362219020188
- ID: 225110
Дәйексөз келтіру
Аннотация
Labetalol was labeled with 188Re. The reaction conditions (amounts of stannous chloride and substrate, pH, time) were optimized, and the radiochemical yield as high as 95 ± 0.4% was reached. Biodistribution in mice was studied. 188Re-Labetalol showed excellent initial heart uptake and good retention. The heart/liver ratios were 5.16, 2.70, and 2.15 at 30, 60, and 120 min post injection, respectively.
Негізгі сөздер
Авторлар туралы
F. Marzook
Labeled Compounds Department, Hot Laboratories Center
Хат алмасуға жауапты Автор.
Email: fawzymarzouk@yahoo.com
Египет, Cairo
H. Ramadan
Radioactive Isotopes and Generator Department, Hot Laboratories Center
Email: fawzymarzouk@yahoo.com
Египет, Cairo
H. Talaat
Labeled Compounds Department, Hot Laboratories Center
Email: fawzymarzouk@yahoo.com
Египет, Cairo
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