Mathematical analysis of codons that stop protein synthesis
- Authors: Kozlov N.N.1, Kugushev E.I.2, Eneeva T.M.1
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Affiliations:
- Keldysh Institute of Applied Mathematics
- Faculty of Mechanics and Mathematics
- Issue: Vol 96, No 3 (2017)
- Pages: 571-573
- Section: Mathematics
- URL: https://journals.rcsi.science/1064-5624/article/view/225420
- DOI: https://doi.org/10.1134/S1064562417060102
- ID: 225420
Cite item
Abstract
A mathematical analysis was performed, which shows that the maximum length of DNA in which translation is possible for at least one of three reading frames for any DNA strand is 10 nucleotides. In the case of any nonstandard stop codon triplet, this number can only decrease. Moreover, for any DNA consisting of at most 11 nucleotides, two and more genes overlaps in plus and minus strands are possible. The probability that a stop codon triplet chosen at random belongs to the group of stop codon triplets with these properties is less than 0.06.
About the authors
N. N. Kozlov
Keldysh Institute of Applied Mathematics
Author for correspondence.
Email: gencodkiam@mail.ru
Russian Federation, Moscow, 125047
E. I. Kugushev
Faculty of Mechanics and Mathematics
Email: gencodkiam@mail.ru
Russian Federation, Moscow, 119992
T. M. Eneeva
Keldysh Institute of Applied Mathematics
Email: gencodkiam@mail.ru
Russian Federation, Moscow, 125047