Physicochemical Properties and Structure of the Bone Matrix in Simulated Tuberculous Osteitis
- 作者: Krut’ko V.1, Kazbanov V.2,3, Musskaya O.1, Gaidash A.2,3, Kulak A.1, Chekan N.4, Serdobintsev M.2, Skrotskaya K.5
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隶属关系:
- Institute of General and Inorganic Chemistry, National Academy of Sciences of Belarus
- St. Petersburg Research Institute of Phthisiopulmonology
- Republican Scientific and Practical Center for Pediatric Surgery
- Physicotechnical Institute, National Academy of Sciences of Belarus
- Research Institute of Physical and Chemical Problems
- 期: 卷 64, 编号 1 (2019)
- 页面: 121-126
- 栏目: Biomedical Physics
- URL: https://journals.rcsi.science/1063-7842/article/view/202754
- DOI: https://doi.org/10.1134/S1063784219010183
- ID: 202754
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详细
The physicochemical properties and structure of the bone matrix are studied in a case of simulated tuberculous osteitis without treatment and after a full course of specific antibacterial therapy. Using X-ray diffraction, infrared spectroscopy, thermal analysis, and scanning electron microscopy, we revealed that tuberculous osteitis causes fine disintegration of the bone matrix due to an increase in nonstoichiometric hydroxyapatite, formation of amorphous calcium phosphates, and a decrease of the organic phase, which is accompanied by embrittlement of the bone matrix. Excessive growth of carbonate-hydroxyapatite crystals of a mixed AB substitution type leads to excessive osteogenesis, accompanied by the uncontrolled growth of bone trabeculae. The presence of “liming” regions in the crystal lattice of hydroxyapatite increases the “binding” properties of the bone matrix in which mycobacteria are immobilized and removed in the composition of detritus.
作者简介
V. Krut’ko
Institute of General and Inorganic Chemistry, National Academy of Sciences of Belarus
Email: tsuber@igic.bas-net.by
白俄罗斯, Minsk, 220079
V. Kazbanov
St. Petersburg Research Institute of Phthisiopulmonology; Republican Scientific and Practical Center for Pediatric Surgery
Email: tsuber@igic.bas-net.by
俄罗斯联邦, St. Petersburg, 191036; Minsk, 220013
O. Musskaya
Institute of General and Inorganic Chemistry, National Academy of Sciences of Belarus
编辑信件的主要联系方式.
Email: tsuber@igic.bas-net.by
白俄罗斯, Minsk, 220079
A. Gaidash
St. Petersburg Research Institute of Phthisiopulmonology; Republican Scientific and Practical Center for Pediatric Surgery
Email: tsuber@igic.bas-net.by
俄罗斯联邦, St. Petersburg, 191036; Minsk, 220013
A. Kulak
Institute of General and Inorganic Chemistry, National Academy of Sciences of Belarus
Email: tsuber@igic.bas-net.by
白俄罗斯, Minsk, 220079
N. Chekan
Physicotechnical Institute, National Academy of Sciences of Belarus
Email: tsuber@igic.bas-net.by
白俄罗斯, Minsk, 220141
M. Serdobintsev
St. Petersburg Research Institute of Phthisiopulmonology
Email: tsuber@igic.bas-net.by
俄罗斯联邦, St. Petersburg, 191036
K. Skrotskaya
Research Institute of Physical and Chemical Problems
Email: tsuber@igic.bas-net.by
白俄罗斯, Minsk, 220030