Bifurcation analysis of the regulation of nociceptive neuronal activity

Abstract

A model of the membrane of a nociceptive neuron from a rat dorsal ganglion has been used to address the problem of analyzing the regulation of nociceptive signals by 5-hydroxy-γ-pyrone-2-carboxylic acid, which is the active pharmaceutic ingredient of the analgesic Anoceptin. The study has applied bifurcation analysis to report the relationship between the values of model parameters and the type of problem solution before and after the parameters change in response to analgesic modulation.