Drosophila as a Model System Used for Searching the Genes, Signaling Pathways, and Mechanisms Controlling Cytoskeleton Formation

Resumo

The regulatory factors and biochemical properties of the actin cytoskeleton are widely studied in vitro and in cell cultures. However, it is still unclear how these factors work in vivo and create an incredible variety of cytoskeleton structures during the organism’s development. Firstly, for the full understanding of formation and functioning of cytoskeleton structures, we need to determine all factors that regulate the structure composition. Secondly, we need to investigate the spatial and temporal mechanisms that provide the coordination of these factors and their activity. Thirdly, we need to know how the regulating factors and structures controlled by them are involved in the development dynamics. This review discusses the innovation methods that made Drosophila a valuable tool for the investigation of these issues.