cGMP and epigenetic factor in the suppression of apoptosis in ovarian follicles
- Авторы: Chakravarthi V.P.1, Sireesha Y.2, Kumar Y.N.3, Siva kumar A.V.1, Bhaskar M.2
-
Учреждения:
- Embryo Biotechnology Laboratory, Department of Physiology
- Division of Animal Biotechnology, Department of Zoology
- Biomedical Informatics Centre, Vector Control Research Centre
- Выпуск: Том 47, № 6 (2016)
- Страницы: 303-312
- Раздел: Reviews
- URL: https://journals.rcsi.science/1062-3604/article/view/183466
- DOI: https://doi.org/10.1134/S1062360416060059
- ID: 183466
Цитировать
Аннотация
The role of cGMP (cyclic guanosine monophosphate) in the suppression of apoptosis in preantral and preovulatory follicles has been established. But the underlying mechanisms have not yet been established. The present study has been focused on revealing the mechanisms involved in the cGMP mediated suppression of apoptosis and in survival of ovarian follicle. cGMP reduces calcium burden of the cell by mediating Ca2+ channels, BK (Big Potassium) channels, phosphatidylinositol 3-kinase (PI3K)/Akt pathway thus, prevents the mitochondrial membrane pore formation and apoptosis. cGMP induces the expression of Trx (thioredoxin) protein and prevents the TNF-α (Tumour Necrosis factor) induced apoptosis. cGMP also induces the expression of cytoskeleton proteins which are involved in heterogeneous distribution of mitochondria and there by reduces the Ca2+ burden and apoptosis. Histone 3 lysine 4 methyltransferase (MLL2) is an epigenetic factor inhibits the transcription of genes involved apoptosis which acts as co-activator of Estrogen receptor-α. In conclusion the present review predicts some mechanisms underlying the cGMP mediated suppression of apoptosis in ovarian follicles.
Ключевые слова
Об авторах
V. Chakravarthi
Embryo Biotechnology Laboratory, Department of Physiology
Автор, ответственный за переписку.
Email: chakravarthi.praveen@gmail.com
Индия, Tirupati, 517502
Y. Sireesha
Division of Animal Biotechnology, Department of Zoology
Email: chakravarthi.praveen@gmail.com
Индия, Tirupati
Y. Kumar
Biomedical Informatics Centre, Vector Control Research Centre
Email: chakravarthi.praveen@gmail.com
Индия, Pondicherry, 60500
A. Siva kumar
Embryo Biotechnology Laboratory, Department of Physiology
Email: chakravarthi.praveen@gmail.com
Индия, Tirupati, 517502
M. Bhaskar
Division of Animal Biotechnology, Department of Zoology
Email: chakravarthi.praveen@gmail.com
Индия, Tirupati
Дополнительные файлы
