The Epac protein inhibitor ESI-09 eliminates the tonic phase of aorta contraction induced by endogenic vasoconstrictors in rats
- Авторы: Sukhanova I.1, Kozhevnikova L.1, Mironova G.2, Avdonin P.2
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Учреждения:
- Scientific Research Institute of General Pathology and Pathophysiology
- Koltzov Institute of Developmental Biology
- Выпуск: Том 44, № 2 (2017)
- Страницы: 179-186
- Раздел: Animal and Human Physiology
- URL: https://journals.rcsi.science/1062-3590/article/view/182378
- DOI: https://doi.org/10.1134/S1062359017020200
- ID: 182378
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Аннотация
It has been shown that the Epac1 and Epac2 protein inhibitor ESI-09 has no effect on the amplitude of contraction of aortic rings caused by the influence of serotonin, noradrenaline, or KCl depolarizing solution, but changes the kinetics of the contractile response. It was noted that in the presence of ESI-09 the curve of the relaxation phase in intact and deendothelized vessels moved to the left under the impact of serotonin or KCl and the phase of prolonged tonic contraction, which developed after the exposure to noradrenalin, was canceled. It was found that ESI-09 exerted different effects on the induced growth in the concentration of cytoplasmic Ca2+ in the aortic smooth muscle cells of rats depending on the agonist, whereas the selective inhibitor Epac2 ESI-05 has no effect on vascular contractility and calcium metabolism in the aortic smooth muscle of rats. The cAMP-independent participation of Epac1 in the formation of the contractile response to the influence of vasoconstrictor compounds was revealed.
Об авторах
I. Sukhanova
Scientific Research Institute of General Pathology and Pathophysiology
Автор, ответственный за переписку.
Email: Irina131280@yandex.ru
Россия, ul. Baltiiskaya 8, Moscow, 125315
L. Kozhevnikova
Scientific Research Institute of General Pathology and Pathophysiology
Email: Irina131280@yandex.ru
Россия, ul. Baltiiskaya 8, Moscow, 125315
G. Mironova
Koltzov Institute of Developmental Biology
Email: Irina131280@yandex.ru
Россия, ul. Vavilova 26, Moscow, 119334
P. Avdonin
Koltzov Institute of Developmental Biology
Email: Irina131280@yandex.ru
Россия, ul. Vavilova 26, Moscow, 119334