A Genetic Predisposition to Chronic Wasting Disease in the Reindeer Rangifer tarandus in the Northern European Part of Russia
- Autores: Kholodova M.1, Baranova A.1, Mizin I.2, Panchenko D.3, Romanenko T.4, Korolev A.5
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Afiliações:
- Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences
- Russian Arctic National Park
- Biology Institute, Karelian Science Center, Russian Academy of Sciences
- Naryan-Mar Branch, Laverov Federal Research Center for Integrated Study of the Arctic, Russian Academy of Sciences
- Institute of Biology, Komi Science Center, Ural Branch of the Russian Academy of Sciences
- Edição: Volume 46, Nº 6 (2019)
- Páginas: 555-561
- Seção: Genetics
- URL: https://journals.rcsi.science/1062-3590/article/view/183110
- DOI: https://doi.org/10.1134/S1062359019060074
- ID: 183110
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Resumo
Nucleotide sequences of the prion protein gene PRNP have been obtained in order to assess potential genetic predisposition to the deadly prion chronic wasting disease (CWD) in three regional groups of wild reindeer and two regional groups of domesticated reindeer Rangifer tarandus in the northern European part of Russia. We report identification of seven single nucleotide polymorphisms corresponding to the substitutions in six codons of the prion protein PrP, namely 2(V/M), 129(G/S), 138(S/N), 169(V/M), 176(N/D), and 225(S/Y). Six alleles of the PrP protein have been described. The genotypes with asparagine (N) in codon 138 (138NN and 138SN), which are associated with higher resistance to CWD, were detected in 8.7, 14.3, and 18.2% of animals in the wild reindeer groups from Novaya Zemlya, Kola Peninsula, and the forest regions of Arkhangelsk oblast and the Komi Republic. It has been found that the frequency of these genotypes in domesticated reindeers from the Komi Republic and Kolguev Island was higher, 37.5 and 42.1%, respectively. It has been noted that due to the predominance of PrP genotypes with serine in codon 138 (138SS), which are associated with increased susceptibility to CWD, and the detection of this disease in reindeer, moose, and red deer in Scandinavia, there exists a real danger that CWD will spread among the reindeer inhabiting the European part of Russia.
Sobre autores
M. Kholodova
Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences
Autor responsável pela correspondência
Email: mvkholod@mail.ru
Rússia, Moscow, 119071
A. Baranova
Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences
Email: mvkholod@mail.ru
Rússia, Moscow, 119071
I. Mizin
Russian Arctic National Park
Email: mvkholod@mail.ru
Rússia, Arkhangelsk, 163000
D. Panchenko
Biology Institute, Karelian Science Center, Russian Academy of Sciences
Email: mvkholod@mail.ru
Rússia, Petrozavodsk, 185910
T. Romanenko
Naryan-Mar Branch, Laverov Federal Research Center for Integrated Study of the Arctic, Russian Academy of Sciences
Email: mvkholod@mail.ru
Rússia, Naryan-Mar, 166000
A. Korolev
Institute of Biology, Komi Science Center, Ural Branch of the Russian Academy of Sciences
Email: mvkholod@mail.ru
Rússia, Syktyvkar, 167982