Physiological Effects of Selank and Its Fragments

Abstract

The development of Selank based on the natural regulatory peptide tuftsin allowed combining the native bioactivity of the molecule with the design engineering of certain physiological functions. Based on a summary of the experimental and clinical data, a comparative analysis of the structural and functional regularities of the effects of Selank and its fragments was performed. The qualitative and quantitative characteristics of correctional processes (anxiolytic, cognitive, immunostimulatory, anti-ulcer, etc.), triggered by the peptide drug and its analogues, are summarized into a single scheme. It is assumed that the Selank effect on the network of cascade processes of peptides and mediators is carried out through enkephalin, the key player of this system.