Heterogeneity of breast cancer I stage: clinical and prognostic value of the carcinoma size T1A, T1B and T1C


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During last 25 years there has been a progressive increase in the share of «small» tumors (T1a and T1b) in breast cancer stage I. Biological characteristics of tumor size T1a, T1b and T1c are different. Tumors less then 5mm have favorable biology: a high rate of luminal A subtype of breast cancer that affects the minimum proportion of relapses of the breast cancer and high rates of long-term survival. Biological characteristics of tumor with T1b and T1c size are more aggressive and presented by a high frequency of ductal carcinoma with luminal B and triple-negative immunophenotype, which significantly decreases the prognosis of the disease. Biology «small» tumors should be considered for choosing the optimal adjuvant treatment algorithm for breast cancer stage I.

作者简介

Irina Kolyadina

Russian Medical Academy of Postgraduate Education; N.N. Blokhin Russian Cancer Research Center

Email: irinakolyadina@yandex.ru
MD, PhD 123995, Moscow, Russian Federation

I. Poddubnaya

Russian Medical Academy of Postgraduate Education; N.N. Blokhin Russian Cancer Research Center

123995, Moscow, Russian Federation

O. Trofimova

N.N. Blokhin Russian Cancer Research Center

115478, Moscow, Russian

G. Frank

Russian Medical Academy of Postgraduate Education

123995, Moscow, Russian Federation

D. Komov

N.N. Blokhin Russian Cancer Research Center

115478, Moscow, Russian

A. Karseladze

N.N. Blokhin Russian Cancer Research Center

115478, Moscow, Russian

A. Ozhereliev

N.N. Blokhin Russian Cancer Research Center

115478, Moscow, Russian

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