Relationship between clinical and morphological parameters and survival in non-small cell lung cancer with protein expression and gene HER2-neu amplification


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Purpose. Study of the content ofprotein HER2 and gene HER2 , CEP17 in conjunction with clinical and morphological parameters and survival in non-small cell lung cancer. Material and methods. Investigated 218 surgery samples of non-small cell lung cancer. HER2 protein was determined by immunohistochemistry (clone 4B5, «Ventana») andgene HER2, CEP17 by hybridization in situ (SISH, «Ventana»). Results. Found relationship between the clinical and morphological parameters on the TNM system with protein HER2 status and CEP17 (for value N), protein HER2 status and gene HER2 amplification (for tumor histogenesis). Survival ofpatients with protein HER2 negative status better than positive status. Found better survival in the absence of gene HER2 amplification and increase CEP17 or gene HER2 amplification in conjunction with increase CEP17, the worse survival - gene HER2 amplification or increase CEP17. In univariate regression analysis protein HER2 status had an impact on survival. Multivariate regression analysis showed no relationship protein HER2 status and gene HER2, CEP17 with patient survival. Conclusion. The content ofprotein HER2 and gene HER2, CEP17 correlated with clinical and morphological parameters and survival of non-small cell lung cancer patients.

作者简介

Dmitriy Kobyakov

Kogalymskaya City Hospital

Email: dskob@yandex.ru
MD, PhD 628481, Kogalym, Russian Federation

A. Avdalyan

N.N. Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences

Altai branch 656049, Barnaul, Russian Federation

A. Lazarev

N.N. Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences

Altai branch 656049, Barnaul, Russian Federation

E. Lushnikova

Research Institute of Regional Pathology and Pathomorphology Siberian Department RAMS

630117, Novosibirsk, Russian Federation

L. Nepomnyaschikh

Research Institute of Regional Pathology and Pathomorphology Siberian Department RAMS

630117, Novosibirsk, Russian Federation

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