Indices of endothelial function in patients with cancer of the digestive tract
- Authors: Olzhayev S.T.1, Lazarev A.F2, Shoykhet Y.N3
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Affiliations:
- Almaty Regional Oncology Center
- N.N. Blokhin Russian Cancer Research Center
- Altai State Medical University
- Issue: Vol 21, No 6 (2016)
- Pages: 300-302
- Section: Articles
- URL: https://journals.rcsi.science/1028-9984/article/view/40302
- DOI: https://doi.org/10.18821/1028-9984-2016-21-6-300-302
- ID: 40302
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Abstract
The aim of the study was the determination of the degree of the pronouncement of the endothelial dysfunction in patients with stomach, pancreatic and liver cancer. Results of clinical-laboratory and instrumental observation of 295 patients with stomach, pancreatic and liver cancer were analysed. The study included 122 patients with stomach cancer, including 87 (71.3%) men and 35 (28.7%) women, aged of 62.2 ± 2.3 years. Pancreatic cancer (95 cases) was found in 52 (54.7%) men and 43 (45.3%) women, aged of 61.7 ± 2.1 years. Patients with liver cancer were presented by 57 (73.1%) men and 21 (26.9%) women, aged of 62.2 ± 3.0 years. The following methods were used: determination of the content of the desquamed endotheliocytes in blood according to Hladovec J. et al.; the maintenance of a von Willebrandfactor (VWF) in serum; Doppler echocardiography test with a reactive hyperemic response of the brachial artery. There was noted the significant increase both of the maintenance of the circulating endotheliocytes and VWF and the decrease in endothelium-dependent vasodilatation in all groups of patients with malignancy. The most considerable changes were revealed in the group ofpatients with a liver cancer. Malfunction of endothelium was associated with the pathological activation of vascular-platelet link of hemostasis system.
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##article.viewOnOriginalSite##About the authors
Sayakhat T. Olzhayev
Almaty Regional Oncology Center
Email: s.olzhayev20@gmail.com
MD, PhD, Head of the Almaty Regional Oncology Center Almaty, 050019, Republic of Kazakhstan
A. F Lazarev
N.N. Blokhin Russian Cancer Research CenterAltaysky branch Barnaul, 656049, Russian Federation
Ya. N Shoykhet
Altai State Medical UniversityBarnaul, 656038, Russian Federation
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