Email this article COMPARISON OF EFFICACY AND TOLERANCE OF THE INTRAPERITONEAL CELL-BASED AND IL-2 IMMUNOTHERAPY OF PATIENTS WITH CHEMOTHERAPY-RESISTANT GASTRIC CANCER AND MALIGNANT ASCITES
- Authors: Titov K.S1, Demidov L.V1, Shubina I.Z.1, Kiselevsky M.V1
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Affiliations:
- N. N. Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences
- Issue: Vol 19, No 3 (2014)
- Pages: 24-28
- Section: Articles
- URL: https://journals.rcsi.science/1028-9984/article/view/40053
- DOI: https://doi.org/10.17816/onco40053
- ID: 40053
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Abstract
Most often gastric cancer is accompanied with abdominal carcinomatosis tumor (metastases) ascites (25 %), which is a life-threatening complications of tumor process, often recurring after systemic drug therapy which not always leads to a longer remission, but is also accompanied by severe side effects. Intraperitoneal immunotherapy of metastatic ascites interleukin-2 (IL-2) in combination with allogeneic (donor) lymphokine - activated killer (LAK) and IL-2 monotherapy is highly effective and well tolerated in patients with gastric cancer. Objective effect of the treatment was 50.0 % and 42.8 %, respectively. Proposed form of immunotherapy can be considered as one of the stages combined drug treatment, has good tolerance and improves their quality of life.
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##article.viewOnOriginalSite##About the authors
K. S Titov
N. N. Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences
Email: ks-titov@mail.ru
канд. мед. наук, хирург-онколог отд-ния биотерапии опухолей НИИ клинической онкологии 115478, Moscow, Russian Federation
L. V Demidov
N. N. Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences115478, Moscow, Russian Federation
I. Zh Shubina
N. N. Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences115478, Moscow, Russian Federation
M. V Kiselevsky
N. N. Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences115478, Moscow, Russian Federation
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