Rare clinical case of diffuse B-large cell lymphoma with laryngeal lesion
- Authors: Kamaeva I.A.1, Lysenko I.B.1, Engibaryan M.A.1, Gusareva M.A.1, Legostaev V.M.1, Lapteva T.O.1, Nikolaeva N.V.1, Gaysultanova Y.S.1, Kapuza E.A.1, Samaneva N.Y.1, Ulyanova Y.V.1, Volkova V.L.1, Bauzhadze M.V.1, Balizkiy G.V.1, Tolmacheva E.A.1
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Affiliations:
- National Medical Research Centre for Oncology
- Issue: Vol 27, No 1 (2022)
- Pages: 29-36
- Section: Case Reports
- URL: https://journals.rcsi.science/1028-9984/article/view/133130
- DOI: https://doi.org/10.17816/onco109580
- ID: 133130
Cite item
Abstract
Diffuse large B-cell lymphoma (DLBCL) is the most common variant of non-Hodgkin’s lymphoma and accounts for 30–60% of all non-Hodgkin’s lymphomas, with increasing incidence increases with age. Currently, the prognosis is assessed using the International Prognostic Index. In recent years, in all European regions, there has been a significant improvement in survival in DLBCL due to the addition of rituximab to standard chemotherapy (CHOP protocol). However, despite significant advances in treatment, long-term remission is only achieved in half of the patients. Laryngeal lesions with this variant of lymphomas is described only in a few articles. There is evidence of various chemotherapeutic regimens effective in this type of lymphoma; in some publications, the authors suggest the use of radiation therapy.
The article presents a clinical case of successful treatment of a patient (chemotherapy + radiation therapy) with diffuse large B-cell lymphoma with laryngeal involvement. with resulting remission. In addition, a review of the literature describing the most common types of lymphomas is presented. The authors set a goal to raise the awareness of physicians about a rare histological variant of laryngeal tumors with a rapid increase in clinical manifestations and the development of life-threatening conditions.
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##article.viewOnOriginalSite##About the authors
Inna A. Kamaeva
National Medical Research Centre for Oncology
Author for correspondence.
Email: inkamaeva@yandex.ru
ORCID iD: 0000-0003-3001-0675
SPIN-code: 8953-3351
Oncologist
Russian Federation, 63 14th line, 344037 Rostov-on-DonIrina B. Lysenko
National Medical Research Centre for Oncology
Email: iralyss@rambler.ru
ORCID iD: 0000-0003-4457-3815
SPIN-code: 9510-3504
MD, Dr. Sci. (Med.), Professor
Russian Federation, 63 14th line, 344037 Rostov-on-DonMarina A. Engibaryan
National Medical Research Centre for Oncology
Email: inkamaeva@yandex.ru
ORCID iD: 0000-0001-7293-2358
SPIN-code: 1764-0276
MD, Dr. Sci. (Med.)
Russian Federation, 63 14th line, 344037 Rostov-on-DonMarina A. Gusareva
National Medical Research Centre for Oncology
Email: inkamaeva@yandex.ru
SPIN-code: 9040-5476
MD, Cand. Sci. (Med.)
Russian Federation, 63 14th line, 344037 Rostov-on-DonVladislav M. Legostaev
National Medical Research Centre for Oncology
Email: inkamaeva@yandex.ru
SPIN-code: 6573-8672
MD, Cand. Sci. (Med.)
Russian Federation, 63 14th line, 344037 Rostov-on-DonTatyana O. Lapteva
National Medical Research Centre for Oncology
Email: lto-96@yandex.ru
SPIN-code: 2771-3213
Russian Federation, 63 14th line, 344037 Rostov-on-Don
Nadezhda V. Nikolaeva
National Medical Research Centre for Oncology
Email: nadya.nikolaeva.74@bk.ru
ORCID iD: 0000-0001-7224-3106
SPIN-code: 4295-5920
MD, Dr. Sci. (Med.)
Russian Federation, 63 14th line, 344037 Rostov-on-DonYakha S. Gaysultanova
National Medical Research Centre for Oncology
Email: yakha.gaysultanova@mail.ru
ORCID iD: 0000-0003-2785-1721
Oncologist
Russian Federation, 63 14th line, 344037 Rostov-on-DonElena A. Kapuza
National Medical Research Centre for Oncology
Email: kapuzaea1967@mail.ru
ORCID iD: 0000-0002-0761-2486
SPIN-code: 4430-1151
Oncologist
Russian Federation, 63 14th line, 344037 Rostov-on-DonNatalya Yu. Samaneva
National Medical Research Centre for Oncology
Email: prettyfairy19@rambler.ru
ORCID iD: 0000-0003-0843-6012
SPIN-code: 1181-0659
MD, Cand. Sci. (Med.)
Russian Federation, 63 14th line, 344037 Rostov-on-DonYulia V. Ulyanova
National Medical Research Centre for Oncology
Email: inkamaeva@yandex.ru
SPIN-code: 1276-9063
MD, Cand. Sci. (Med.)
Russian Federation, 63 14th line, 344037 Rostov-on-DonViktoria L. Volkova
National Medical Research Centre for Oncology
Email: inkamaeva@yandex.ru
ORCID iD: 0000-0003-2674-0755
SPIN-code: 8289-6300
MD, Cand. Sci. (Med.)
Russian Federation, 63 14th line, 344037 Rostov-on-DonMamuka V. Bauzhadze
National Medical Research Centre for Oncology
Email: inkamaeva@yandex.ru
SPIN-code: 5315-3382
MD, Cand. Sci. (Med.)
Russian Federation, 63 14th line, 344037 Rostov-on-DonGennadiy V. Balizkiy
National Medical Research Centre for Oncology
Email: inkamaeva@yandex.ru
SPIN-code: 4090-2703
Russian Federation, 63 14th line, 344037 Rostov-on-Don
Ekaterina A. Tolmacheva
National Medical Research Centre for Oncology
Email: inkamaeva@yandex.ru
SPIN-code: 2376-0705
MD, Cand. Sci. (Med.)
Russian Federation, 63 14th line, 344037 Rostov-on-DonReferences
- World Health Organization. WHO classification of tumours of haematopoietic and lymphoid tissues. Volume 2. Swerdlow SH, Campo E, Harris NL, Jaffe ES, et al, editors. Lyon: International agency for research on cancer; 2017.
- Ollila TA, Olszewski AJ. Extranodal diffuse large B cell lymphoma: molecular features, prognosis, and risk of central nervous system recurrence. Curr Treat Options Oncol. 2018;19(8):38. doi: 10.1007/s11864-018-0555-8
- Zykova TA, Engibarjan MA, Pustovaja IV., i dr. Vyjavleny razlichija serologicheskogo profilja inficirovanija virusom Jepshtejna-Barr u bol’nyh s opuholjami oblasti golovy/shei i limfomami. In: Materialy V Peterburgskogo mezhdunarodnogo onkologicheskogo foruma «Belye nochi»; 2019 Jun 20–23; Saint-Petersburg. Saint-Petersburg: Avtonomnaja nekommercheskaja nauchno-medicinskaja organizacija «Voprosy onkologii»; 2019. P. 116.
- Kamaeva IA, Lysenko IB, Nikolaeva NV, et al. The use of immunotherapy for the treatment of refractory forms of Hodgkin lymphoma in real clinical practice. South Russian Journal of Cancer. 2021;2(2):34–41. doi: 10.37748/2686-9039-2021-2-2-4
- Kit OI, Kamaeva IA, Lysenko IB. Primary mediastinal large B-cell lymphoma with a rare ALK gene mutation. Advances in Molecular Oncology. 2022;9(2):105–110. doi: 10.17650/2313-805X-2022-9-2-105-110
- Sharma V, Gupta S, Patel M, et al. Diffuse large B cell lymphoma of larynx. J Assoc Physicians India. 2018;66(5):91–93.
- Zhao P, Zhou Y, Li J. Primary laryngeal lymphoma in China: a retrospective study of the last 25 years. J Laryngol Otol. 2019;133(9):792–795. doi: 0.1017/S0022215119001622
- Horny HP. The larynx in lymphoproliferative and myeloproliferative diseases. Part II: Laryngeal autopsy findings and discussion. HNO. 1994;42(7):398–404. (In German).
- Ng C, Mentias Y, Abdelgalil A. Imaging features of non-epithelial tumours of the larynx. Clin Radiol. 2020;75(9):711.e5–711.e12. doi: 10.1016/j.crad.2020.01.013
- Belousova NV, Poddubnyj BK, Ungiadze GV, et al. Jendoskopicheskaja semiotika i diagnostika limfom glotochnogo kol’ca Pirogova–Val’dejera. Journal of Modern Oncology. 2005;7(3):118–121.
- Kato S, Sakura M, Takooda S, et al. Primary non-Hodgkin’s lymphoma of the larynx. J Laryngol Otol. 1997;111(6):571–574. doi: 10.1017/s0022215100137946
- Andratschke M, Stelter K, Ihrler S, Hagedorn H. Subglottic tracheal stenosis as primary manifestation of a marginal zone B-cell lymphoma of the larynx. In Vivo. 2005;19(3):547–550.
- Chaker K, Beghdad M, Mennouni MA, Mkhatri A, et al. Primary laryngeal T-cell lymphoma: a case report and review of the literature. Int J Surg Case Rep. 2021;82:105858. doi: 10.1016/j.ijscr.2021.105858
- Liu D, Qian T, Sun S, Jiang JJ. Laryngopharyngeal reflux and inflammatory responses in mucosal barrier dysfunction of the upper aerodigestive tract. J Inflamm Res. 2021;13:1291–1304. doi: 10.2147/JIR.S282809
- Johnson AO, Stevens BP, Lam JT, Schweinfurth JM. Two cases of rare subglottic MALT lymphoma of the larynx. Am J Otolaryngol. 2020;41(6):102736. doi: 10.1016/j.amjoto.2020.102736
- Franzen A. Kurrer MO. Malignant lymphoma of the larynx: a case report and review of the literature. Laryngorhinootologie. 2000;79(10):579–583. (In German). doi: 10.1055/s-2000-7678