INFLUENCE OF CYTOKINES ON BIOFILM FORMATION OF INTESTINAL MICROSYMBIONTS

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The multidirectional effect of recombinant cytokines (TNF-α, IL-10) on the biofilm formation of intestinal microsymbionts was established, which depended on the concentration of cytokines, the type and strain of microorganisms.

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I. Chainikova

FGBUN Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences;
GBOU VPO «Orenburg State Medical University» of the Ministry of Health of the Russian Federation

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Email: inchainicova@yandex.ru

M.D., professor, Leading Researcher Institute of Cellular and Intracellular Symbiosis;

Professor of the Department of Normal Physiology,

Orenburg

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E. Ivanova

FGBUN Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences;
GBOU VPO «Orenburg State Medical University» of the Ministry of Health of the Russian Federation

Email: fake@neicon.ru

MD, Leading Researcher Institute of Cellular and Intracellular Symbiosis;

docent of the Department of Pharmaceutical Chemistry,

Orenburg

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T. Bondarenko

FGBUN Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences

Email: fake@neicon.ru

Researcher Institute of Cellular and Intracellular Symbiosis,

Orenburg

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N. Perunova

FGBUN Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences

Email: fake@neicon.ru

MD, Professor of the Russian Academy of Sciences, Head of the Laboratory of Biomonitoring and Molecular Genetic Research,

Orenburg

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O. Chelpachenko

FGBUN Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences

Email: fake@neicon.ru

M.D., Leading Researcher Institute of Cellular and Intracellular Symbiosi, 

Orenburg

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I. Nikiforov

FGBUN Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences

Email: fake@neicon.ru

Ph. D., Leading Researcher Institute of Cellular and Intracellular Symbiosi,

Orenburg

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参考

  1. Högbom M., Ihalin R. Functional and structural characteristics of bacterial proteins that bind host cytokines. Virulence. 2017, 8(8), 1592–1601.
  2. Lee J-H, Sorbo L., Khine A. A., Azavedo J., Low D. E., Bell D., Uhlig S., Slutsky A. S., Zhang H. Modulation of Bacterial Growth by Tumor Necrosis Factor-α In Vitro and In Vivo. American Journal of Respiratory and Critical Care Medicine. 2003, 168 (12), 1462–1470.
  3. O’Toole G.A., Kolter R. Initiation of biofilm formation in Pseudomonas fluorescens WCS365 proceeds via multiple, convergent signalling pathways: a genetic analysis. Mol. Microbiol. 1998, 28 (3), 449–61.

版权所有 © Chainikova I.N., Ivanova E.V., Bondarenko T.A., Perunova N.B., Chelpachenko O.E., Nikiforov I.A., 2019

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