HLA-DRB1* ASSOCIATIONS WITH SPORADIC SEPTAL CONGENITAL HEART DISEASES WITHOUT CHROMOSOMAL DISEASES
- 作者: Tsepokina A.1, Deev N.1,2, Shmulevich S.3, Shabaldin A.1,2, Korostelev A.3, Ponasenko A.1
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隶属关系:
- Federal state budgetary scientific institution “Research Institute of complex problems of cardiovascular diseases”
- Federal state budgetary educational institution of higher education “Kemerovo state medical University” of the Ministry of health of the Russian Federation
- State budgetary institution of health care “Kemerovo regional clinical cardiology clinic named after academician L. S. Barbarash”
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 617-619
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/120320
- DOI: https://doi.org/10.31857/S102872210006991-5
- ID: 120320
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全文:
详细
Associations of HLA-DRB1* alleles were determined with sporadic septal congenital heart defects in children. 97 children (44 boys and 53 girls) with an isolated ventricular septal defect (VSD) without chromosomal diseases and anomalies were examined. Surveyed 132 healthy children (control group). The frequency of occurrence of 14 alleles of the HLA-DRB1 gene (01, 04, 07, 08, 09, 10, 11, 12, 13, 14, 15, 16, 17, 18). Mathematical processing was performed using the STATISTICA 8.0 application package (StatSoftInc., USA). It was revealed that in children with sporadic CHD without chromosomal diseases, HLA-DRB1*15 (p = 0.03) was signifi cantly more frequent in the genotype compared with the control group. The formation of sporadic septal congenital heart defects without chromosomal diseases is positively associated with HLA-DRB1*15.
作者简介
A. Tsepokina
Federal state budgetary scientific institution “Research Institute of complex problems of cardiovascular diseases”
编辑信件的主要联系方式.
Email: fake@neicon.ru
junior researcher of the laboratory of genomic medicine,
Moscow
俄罗斯联邦N. Deev
Federal state budgetary scientific institution “Research Institute of complex problems of cardiovascular diseases”;Federal state budgetary educational institution of higher education “Kemerovo state medical University” of the Ministry of health of the Russian Federation
Email: fake@neicon.ru
laboratory assistant-researcher of the laboratory of cellular technologies,
Moscow
俄罗斯联邦S. Shmulevich
State budgetary institution of health care “Kemerovo regional clinical cardiology clinic named after academician L. S. Barbarash”
Email: fake@neicon.ru
PhD, head of children’s Department,
Moscow
俄罗斯联邦A. Shabaldin
Federal state budgetary scientific institution “Research Institute of complex problems of cardiovascular diseases”;Federal state budgetary educational institution of higher education “Kemerovo state medical University” of the Ministry of health of the Russian Federation
Email: weit2007@yandex.ru
M.D., leading researcher of laboratory of cell technologies,
Moscow
俄罗斯联邦A. Korostelev
State budgetary institution of health care “Kemerovo regional clinical cardiology clinic named after academician L. S. Barbarash”
Email: fake@neicon.ru
M.D., professor of the Department of microbiology, immunology. virology,
Moscow
俄罗斯联邦A. Ponasenko
Federal state budgetary scientific institution “Research Institute of complex problems of cardiovascular diseases”
Email: fake@neicon.ru
Ph.D., head of the Department of Genomic Medicine,
Moscow
俄罗斯联邦参考
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- Mjosberg J., Berg G., Jenmalm M. C., Ernerudh J. FOXP3+ regulatory T cells and T helper 1, T helper 2, and T helper 17 cells in human early pregnancy deciduas. Biol Reprod. 2010. Apr; 82(4): 698–705. doi: 10.1095/biolreprod.109.081208. Epub 2009 Dec 16.
