EARLY CYTOKINE PREDICTORS OF ACUTE REJECTION OF KIDNEY TRANSPLANT

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The study of the protective role of blood cytokines evaluated by multiplex analysis before kidney transplantation in recipients with chronic kidney disease showed that the predictors of acute kidney transplant rejection in recipients can be considered high plasma levels of IL-17A, IL-1RA, IL-33, CCL2, as well as BDNF and ccl1 defi ciency. The early signs of a favorable post-transplant period are complete absence or extremely low levels of IL-1β, IL-6, IL-17A, decreased levels of LIF, IL-33, CXCL12), as well as high levels of CXCL8, CXCL10, IFNγ and CCL5.

作者简介

T. Fedorenko

“Kuban state medical University” of the Ministry of health care of the Russian Federation;
Regional coordination center of organ donation of the Regional clinical hospital № 1

编辑信件的主要联系方式.
Email: fake@neicon.ru

post-graduate student of the Department of Clinical immunology, allergology and laboratory diagnostics;

laboratory biologist,

Krasnodar

俄罗斯联邦

N. Kolesnikova

“Kuban state medical University” of the Ministry of health care of the Russian Federation

Email: nvk24071954@mail.ru

professor of the Department of Clinical immunology, allergology and laboratory diagnostics,

Krasnodar

俄罗斯联邦

I. Pashkova

Regional coordination center of organ donation of the Regional clinical hospital № 1

Email: fake@neicon.ru

professor of the Department of Clinical immunology, allergology and laboratory diagnostics,

Krasnodar

俄罗斯联邦

参考

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  2. Cozzi E., Calabrese F., Schiavon M., Feltracco P., Seveso M., Carollo C. Loy M, Cardillo M, Rea F. Immediate and catastrophic antibody-mediated rejection in a lung transplant recipient with anti-angiotensin II receptor type 1 and anti-endothelin-1 receptor type A antibodies.Am J Transplant, 2017, 17, 557–564.
  3. Rotondi M., Netti G. S., Lazzeri E., Stallone G., Bertoni E., Chiovato L., Grandaliano G., Gesualdo L., Salvadori M., Schena F.P., Romagnani P., Serio M. High pretransplant serum levels of CXCL9 are associated with increased risk of acute rejection and graft failure in kidney graft recipients. TransplInt, 2010, 23, 465–475.
  4. Lemaître P. H., Vokaer B., Charbonnier L. M. Iwakura Y., Estenne M., Goldman M., Leo O., Remmelink M., Le Moine A. IL-17A mediates early post-transplant lesions after heterotopic trachea allotransplantation in Mice. PloS one, 2013, 8, 7, 70236.
  5. Yin X. T., Zobell S., Jarosz J. G. Stuart P. M. Anti–IL-17 Therapy Restricts and Reverses Late-Term Corneal Allorejection. The Journal of Immunology, 2015, 194, 8. – С. 4029–4038.
  6. Lo D. J., Kaplan B., Kirk A. D. Biomarkers for kidney transplant rejection. Nat Rev Nephrol., 2014, 10, 215– 225.

版权所有 © Fedorenko T.V., Kolesnikova N.V., Pashkova I.A., 2019

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此作品已接受知识共享署名 4.0国际许可协议的许可
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