EXPERIMENTAL MICE SEPSIS MODELS: ADVANTAGES AND PITFALLS
- 作者: Starkina O.1, Ilyukina N.1, Vassilev T.1
-
隶属关系:
- Lobachevsky State University of Nizhniy Novgorod
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 566-568
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/120303
- DOI: https://doi.org/10.31857/S102872210006976-8
- ID: 120303
如何引用文章
全文:
详细
Sepsis is studied in vivo by using experimental mice models. The golden standard is the model which utilizes peritonitis induction by cecal ligation and puncture. Lipopolysacharide injection is often used for induction of septic process as well. Currently, the researches discuss disadvantages of these models and poor modeling capability of mice sepsis compared to septic processes which take place in humans. The throughout discussion is present in the article by Cavaillon J. M. “New Approaches to Treat Sepsis: Animal Models Do Not Work” [1]. In this review the author questioned the sepsis animal models used nowadays, but he didn’t mentioned the experimental model described by Gonnert F. A. et al. in their work «Characteristics of Clinical Sepsis Refl ected in a Reliable and Reproducible Rodent Sepsis Model». Our review briefl y discusses the advantages of this model compared to the other animal sepsis models.
作者简介
O. Starkina
Lobachevsky State University of Nizhniy Novgorod
编辑信件的主要联系方式.
Email: fake@neicon.ru
junior scientist, Neurotechnologies Department,
Nizhniy Novgorod
俄罗斯联邦N. Ilyukina
Lobachevsky State University of Nizhniy Novgorod
Email: fake@neicon.ru
student,
Nizhniy Novgorod
俄罗斯联邦T. Vassilev
Lobachevsky State University of Nizhniy Novgorod
Email: tchavdarv@gmail.com
senior scientist, Neurotechnologies Department,
Nizhniy Novgorod
俄罗斯联邦参考
- Jean-Marc Cavaillon. New Approaches to Treat Sepsis: Animal Models «Do Not Work» (Review), General Reanimatology, 2018, 14; 3.
- Jean-Louis Vincent. Increasing awareness of sepsis: World Sepsis Day, Critical Care. 2012, 16:152.
- Gingles N. A., Alexander J. E., Kadioglu A., Andrew P. W., Kerr A., Mitchell T. J., Hopes E., Denny P., Brown S., Jones H. B., Little S., Booth G. C., McPheat W. L. Role of genetic resistance in invasive pneumococcal infection: identification and study of susceptibility and resistance in inbred mouse strains. Infect. Immun. 2001, 69 (1): 426–34.
- Angele M. K., Pratschke S., Hubbard W. J., Chaudry I. H. Gender differences in sepsis: cardiovascular and immunological aspects. Virulence. 2014,1; 5(1):12–9.
- Falk A. Gonnert M. D., Peter Recknagel, Madlen Seidel, Nayla Jbeily, M. S., Katja Dahlke, Clemens L. Bockmeyer, M.D., Johannes Winning, M.D, Wolfgang Losche, M.D., Ralf A. Claus and Michael Bauer, M.D. Characteristics of Clinical Sepsis Reflected in a Reliable and Reproducible Rodent Sepsis Model, Journal of Surgical Research. 2011, 170, 123.
- Dyson A., Singer M. Animal models of sepsis: Why does preclinical efficacy fail to translate to the clinical setting? Crit Care Med. 2009,;37(1 Suppl):30–7.
- Dan M., Richardson J., Miliotis M. D., Koornhof H. J. Comparison of preservation media and freezing conditions for storage of specimens of feces, J Med Microbiol. 1989, 28(2):151–4.
