DIFFERENTIATION OF CD8+ LYMPHOCYTES AND THEIR CYTOLYTIC ACTIVITY IN WOMEN WITH THREATED PRETERM LABOR
- 作者: Sotnikova N.1, Borzova N.1, Radjabova N.1
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隶属关系:
- Federal State Institution “Ivanovo Research Institute of Maternity and Childhood named after V. N. Gorodkov” the Ministry of Health of the Russian Federation
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 563-565
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/120302
- DOI: https://doi.org/10.31857/S102872210006975-7
- ID: 120302
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详细
The aim of this work was to determine the features of diff erentiation of effector cytotoxic T lymphocytes (CTL) in women with threated preterm labor. Under observation were 100 pregnant women of 24–34 weeks of pregnant: the main group consisted of 44 women with threated preterm labor, control group – of 56 women with uncomplicated course of gestation. The relative content of CD8 cells, CD8 naïve cells (Tn), CD8 memory cells: Central (Tcm), preterminal-differentiated (Tem) and terminal differentiated (Temra) was studied in perephiral bloded. The content of CD8 cells producing Perforin was assessed in the total population of lymphocytes (CD8 Perf), as well as in populations of CD8 Tcm, Tem, Temra cells. The results of the study showed that women with threated preterm labor was characterized by a significant increase in the relative content of CD8 and CD8 Perf+ lymphocytes. The content of naive cells was significantly increased in the population of CD8 CTLs in women with exercise. In addition, there was a significant increase compared to that in control group the content of Perforin-producing cells in the fractions of Tcm, Tem and Temra cell memory.
作者简介
N. Sotnikova
Federal State Institution “Ivanovo Research Institute of Maternity and Childhood named after V. N. Gorodkov” the Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: fake@neicon.ru
MD, head of the laboratory of clinical immunology,
Ivanovo
俄罗斯联邦N. Borzova
Federal State Institution “Ivanovo Research Institute of Maternity and Childhood named after V. N. Gorodkov” the Ministry of Health of the Russian Federation
Email: fake@neicon.ru
MD, assistant professor, senior researcher of Department of obstetrics and gynecology,
Ivanovo
俄罗斯联邦N. Radjabova
Federal State Institution “Ivanovo Research Institute of Maternity and Childhood named after V. N. Gorodkov” the Ministry of Health of the Russian Federation
Email: nailaradjabova@yandex.ru
junior researcher of the Department of Obstetrics and Gynecology Neonatology,
Ivanovo
俄罗斯联邦参考
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