LEADING MECHANISMS OF IMMUNOPATHOGENESIS IN VARIOUS TYPES OF INFLAMMATION (INFECTIOUS, AUTOIMMUNE, ATOPIC)
- 作者: Salmasi J.1, Poryadin G.1, Kazimirsky A.1
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隶属关系:
- Federal State Budget Institution of Higher Education “Pirogov Russian National Research Medical University» Ministry of Health of the Russian Federation
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 518-520
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/120288
- DOI: https://doi.org/10.31857/S102872210006950-0
- ID: 120288
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详细
The purpose of this study was to identify the leading mechanisms of immunopathogenesis of inflammation diseases of different genesis. Using the indirect immune fluorescence method, the number of lymphocytes carrying surface receptors CD3, CD4, CD8, CD16, CD56, CD20, CD72, mIgM, mIgG, CD23, CD25, CD71, HLA-DR, CD54, CD95, CD30, CD38, CD178. Lymphocytes of patients with aseptic inflammation showed an increase in the number of CD25, CD71, and HLA-DR lymphocytes – markers of activation. But the complete absence of lymphocyte activation was found in severe cases of infectious inflammatory process in patients with osteomyelitis. In autoimmune inflammation, the lymphocytes activation process has a high intensity and is accompanied by a weakening of the expression of the activation receptor apoptosis CD95. Atopic diseases (atopic dermatitis and atopic bronchial asthma) are characterized by an intense lymphocytes activation process, which is accompanies with a significant decrease in the number of CD95+ lymphocytes, but different by another lymphocytes subpopulations.
作者简介
J. Salmasi
Federal State Budget Institution of Higher Education “Pirogov Russian National Research Medical University» Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: profjms@yandex.ru
PhD, MD (Medicine), Head of the Department of Pathophysiology and Clinical Pathophysiology, Faculty of Medicine,
Moscow
俄罗斯联邦G. Poryadin
Federal State Budget Institution of Higher Education “Pirogov Russian National Research Medical University» Ministry of Health of the Russian Federation
Email: fake@neicon.ru
PhD, MD (Medicine), Corresponding Member, Russian Academy of Sciences, Professor, Department of Pathophysiology and Clinical Pathophysiology, Faculty of Medicine,
Moscow
俄罗斯联邦A. Kazimirsky
Federal State Budget Institution of Higher Education “Pirogov Russian National Research Medical University» Ministry of Health of the Russian Federation
Email: fake@neicon.ru
PhD, MD (Biology), Leading Researcher of the Department of Molecular Technologies,
Moscow
俄罗斯联邦参考
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