APPLICATION OF GENOTYPING CYP3A5 POLYMORPHISM FOR CORRECTING DOSE OF TACROLIMUS IN KIDNEY TRANSPLANTATION
- 作者: Ruzibakiyeva M.1, Aripova T.1, Hadzhibaev F.2, Sharipov V.2, Azizova Z.1
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隶属关系:
- Institute of Human Immunology and Genomics, Academy of Sciences of Uzbekistan
- Republican Specialized Scientific Center for Emergency Medical Aid of the Ministry of Health of the Republic of Uzbekistan
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 499-502
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/120281
- DOI: https://doi.org/10.31857/S102872210006944-3
- ID: 120281
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Currently, according to standard immunosuppression protocols after organ transplantation, tacrolimus is used as a part of immunosuppressive therapy. Along with obtaining the desired immunosuppressive effect, the problem of the development of unwanted adverse reactions to this drug is highly relevant. Pharmacogenetic testing of genotyping of the polymorphism of CYP3A5 G6986A, allows a personalized approach to the selection of the dosing regimen of tacrolimus, may increase the number of patients in whom the concentration of tacrolimus will be within the therapeutic range and will not exceed the acceptable toxicity level.
作者简介
M. Ruzibakiyeva
Institute of Human Immunology and Genomics, Academy of Sciences of Uzbekistan
编辑信件的主要联系方式.
Email: malika-ruz@hotmail.com
PhD, Senior Researcher,
Tashkent
乌兹别克斯坦T. Aripova
Institute of Human Immunology and Genomics, Academy of Sciences of Uzbekistan
Email: fake@neicon.ru
MD, Academician of the Academy of Sciences of Uzbekistan, Director of the Institute,
Tashkent
乌兹别克斯坦F. Hadzhibaev
Republican Specialized Scientific Center for Emergency Medical Aid of the Ministry of Health of the Republic of Uzbekistan
Email: fake@neicon.ru
D.M.S., Head of Surgery Department,
Tashkent
乌兹别克斯坦V. Sharipov
Republican Specialized Scientific Center for Emergency Medical Aid of the Ministry of Health of the Republic of Uzbekistan
Email: fake@neicon.ru
MD, Head of the Department of Anaesthesiology and Reanematology,
Tashkent
乌兹别克斯坦Z. Azizova
Institute of Human Immunology and Genomics, Academy of Sciences of Uzbekistan
Email: fake@neicon.ru
junior researcher,
Tashkent
乌兹别克斯坦参考
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