THEINNATE IMMUNITY CELLS IN THE PATHOGENESIS OF TRAUMATIC BRAIN INJURY

The content of innate immunity cells expressing CD45, CD14, CD16, CD11b and F4 / 80 receptors brain in experimental modeling of traumatic brain injury (TBI) was studed. It was established that the number of CD16/11b positive macrophages of the M1 subpopulation increased in microgy on the 2nd day after TBI and signifi cantly enlarged up to 8 days. In the corpus callosum and the ipsilateral area of the striatum, CD16/11b expressed cells also peaked 8 days after TBI and correlated with an increase in the positive response to the presence of the endothelial antigen SMI71. Signifi cant structural transformations of the nervous tissue and the output of peripheral immune cells, coupled with impaired permeability by the blood-brain barrier, were shown. The disturbance of regulatory changes neuroimmune connections in TBI was proved.