EXPRESSION OF IMMUNE RESPONSE GENES IN CHRONICALLY IRRADIATED PERSONS AT LATE PERIOD AFTER EXPOSURE

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At late period after exposure a decrease in the level of NF-kB1gene expression and an increase in the level of PAD4 gene expressionwere registered in exposed persons. Considering the dependence of some immunity parameters on the levels of NF-kB1 and PAD4geneexpression, it can be assumed that changes in the immunity of exposed personsin the remote period can be mediated by changes in transcriptional activity of genes.

作者简介

A. Akleyev

Urals Research Center for Radiation Medicine of the FMBA of Russia;
Southern-Urals State Medical University of the RF Ministry of Public Health

编辑信件的主要联系方式.
Email: andrey.akleev@yandex.ru

Senior researcher of Molecular-cell Radiobiology Laboratory;

M.D., PhD, Associate Professor of the Department of Microbiology, Virology, Immunology and Clinical Laboratory Diagnostics,

Chelyabinsk

俄罗斯联邦

V. Nikiforov

Urals Research Center for Radiation Medicine of the FMBA of Russia;
Chelyabinsk State University

Email: fake@neicon.ru

Junior researcher of Molecular-cell Radiobiology Laboratory;

Postgraduate student of the Department of Radiation Biology, 

Chelyabinsk

俄罗斯联邦

E. Blinova

Urals Research Center for Radiation Medicine of the FMBA of Russia;
Chelyabinsk State University

Email: fake@neicon.ru

PhD, Head of Molecular-cell Radiobiology Laborator;

Associate Professor of the Department of Radiation Biology,

Chelyabinsk

俄罗斯联邦

I. Dolgushin

Southern-Urals State Medical University of the RF Ministry of Public Health

Email: fake@neicon.ru

M.D., Professor, Academician of the Russian Academy of Sciences, Head of Microbiology, Virology, Immunology and Clinical Laboratory Diagnostics Department,

Chelyabinsk

俄罗斯联邦

参考

  1. Шуленина Л. В., Ушенкова Л. Н., Ледин Е. В., Шагирова Ж. М., Раева Н. Ф., Засухина Г. Д., Михайлов В. Ф. Экспрессия генов Р53, NPM1, Кras, с-Мус, P14АRF в крови онкологических больных до и после лучевой терапии. Радиационная биология. Радиоэкология. 2012, 52 (6), 572–581.
  2. Database of metabolic pathways KEGG PATHWAY Database. 2018. URL: http://www.genome.jp/kegg/pathway.html.

版权所有 © Akleyev A.A., Nikiforov V.S., Blinova E.A., Dolgushin I.I., 2019

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