PECULIARITIES OF IMMUNE RESPONSE TO MEASLES VACCINATION IN SERONEGATIVE ADULTS
- 作者: Smerdova M.1, Andreev Y.1, Toptygina A.1
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隶属关系:
- G. N. Gabrichevsky Research Institute for Epidemiology and Microbiology
- 期: 卷 22, 编号 2-2 (2019)
- 页面: 1021-1023
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/120248
- DOI: https://doi.org/10.31857/S102872210006485-8
- ID: 120248
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全文:
详细
100 healthy adults aged 18–30 years were examined for the presence of measles immunity. A protective level of measles antibodies was found in 32%, and in 68% of adults such antibodies were not detected. Specific cellular immunity to measles virus antigens was detected in 57.37% of the examined individuals, in 26.07% of them specific cellular immunity to measles viruses was not detected, and in 6.56% the response was regarded as equivocal. Seronegative adults were vaccinated with measles cultural live vaccine (“Vector”, Russia). After 6 weeks, protective levels of anti-measles antibodies were detected in all vaccinated patients, the average level was 2.18 (1.40‒3.68) IU/ml. Specific cellular immunity to antigens of measles viruses in 3 people was regarded as equivocal, in the rest of the vaccinated as positive.
作者简介
M. Smerdova
G. N. Gabrichevsky Research Institute for Epidemiology and Microbiology
Email: fake@neicon.ru
PhD Student, Laboratory of Cytokines,
Moscow
俄罗斯联邦Yu. Andreev
G. N. Gabrichevsky Research Institute for Epidemiology and Microbiology
Email: fake@neicon.ru
PhD Student, Laboratory of Cytokines,
Moscow
俄罗斯联邦A. Toptygina
G. N. Gabrichevsky Research Institute for Epidemiology and Microbiology
编辑信件的主要联系方式.
Email: toptyginaanna@rambler.ru
PhD, MD (Medicine), Leading Research Associate, Laboratory of Cytokines,
Moscow
俄罗斯联邦参考
- Filia A., Bella A., Del Manso M., Baggieri M., Magurano F., Rota M. C. Ongoing outbreak with well over 4,000 measles cases in Italy from January to end August 2017 – what is making elimination so difficult? Euro Surveill, 2017, 22(37), 30614.
- Топтыгина А. П., Смердова М. А., Наумова М. А., Владимирова Н. П., Мамаева Т. А. Влияние особенностей популяционного иммунитета на структуру заболеваемости корью и краснухой. Инфекция и иммунитет, 2018, 8(3), 341–348.
- Топтыгина А. П., Семикина Е. Л., Алешкин В. А. Формирование и поддержание специфического клеточного ответа на вакцинацию «Приорикс». Иммунология, 2013, 34(5), 257–261.
