CYTOKINE DYNAMICS AS A RESULT OF PHYTO-FLAVANOID EXPOSURE IN WOMEN WITH UTERINE MYOMA
- 作者: Narzullaeva N.1, Musakhodzhaeva D.2, Abdurakhmanov M.1, Ikhtiyarova G.1
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隶属关系:
- Bukhara Medical Institute named after Abu Ali ibn Sino
- Institute of Human Immunology and Genomics, Academy of Sciences of the Republic of Uzbekistan
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 435-437
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/120245
- DOI: https://doi.org/10.31857/S102872210006922-9
- ID: 120245
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全文:
详细
A study was conducted to study the effectiveness of the use of the herbal preparation Bioflazid in 28 women with a simple form of uterine fibroids. The levels of pro- (IL-6, IL-8, IL-18, and TNFα) and anti-inflammatory (IL-10) cytokines in serum were studied. Positive dynamics of both clinical parameters and levels of studied cytokines was revealed.
作者简介
N. Narzullaeva
Bukhara Medical Institute named after Abu Ali ibn Sino
编辑信件的主要联系方式.
Email: fake@neicon.ru
ass. of Department of Obstetrics and Gynecology,
Bukhara
乌兹别克斯坦D. Musakhodzhaeva
Institute of Human Immunology and Genomics, Academy of Sciences of the Republic of Uzbekistan
Email: dilym@mail.ru
DSc, Head of the Laboratory of Immunology of Reproduction,
Tashkent
乌兹别克斯坦M. Abdurakhmanov
Bukhara Medical Institute named after Abu Ali ibn Sino
Email: fake@neicon.ru
DSc., professor,
Bukhara
乌兹别克斯坦G. Ikhtiyarova
Bukhara Medical Institute named after Abu Ali ibn Sino
Email: fake@neicon.ru
PhD, Department of Obstetrics and Gynecology,
Bukhara
乌兹别克斯坦参考
- Буянова С. Н., Щукина Н. А., Бабунашвили Е. Л. Биологическая роль, терапевтический потенциал фитофлавоноидов, витамина D в лечении больных с миомой матки и другие перспективные фармакологические направления //Ж. Российский вестник акушера-гинеколога., 2018;18(5)., С. 36–42.
- Shushan A., Ben-Bassat H., Mishani E., Laufer N., Klein B. Y., Rojansky N. Inhibition of leiomyoma cell proliferation in vitro by genistein and the protein tyrosine kinase inhibitor TKS050. Fertility and Sterility. 2007; 87: 1: 127–135. https://doi.org/10.1016/j.fertnstert.2006.05.056
- Miyake A., Takeda T., Isobe A., Wakabayashi A., Nishimoto F., Morishige K.I., Kimura T. Repressive effect of the phytoestrogen genistein on estradiol-induced uterine leiomyoma cell proliferation. Gynecological Endocrinology. 2009; 25: 6: 403–409. https://doi.org/10.1080/09513590902730804
- Di X., Andrews D. M., Tucker C. J., Yu L., Moore A. B., Zheng X., Dixon D. A high concentration of genistein down-regulates activin A, Smad3 and other TGF-β pathway genes in human uterine leiomyoma cells. Experimental and Molecular Medicine. 2012; 44: 4: 281– 292. https://doi.org/0,3858/emm.2012.44.4.024
- Castro L., Gao X., Moore A. B., Yu L., Di X., Kissling G. E., Dixon D. High Concentration of Genistein Induces Cell Death in Human Uterine Leiomyoma Cells by Autophagy. Expert OpinEnviron Biol. 2016; 5: Suppl 1. https://dx.doi.org/10.4172/2325-9655.S1-003
