OBTAINING AND PRECLINICAL STUDIES OF RECOMBINANT PSEUDOMONAS VACCINE

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Three experimental lots of Recombinant Pseudomonas Vaccine (RPV) consisting a complex of the recombinant outer membrane protein F (OprF) and the recombinant toxoid that were sorbed on aluminum hydroxide have been obtained. During preclinical studies, we confi rmed the immunogenicity of the vaccine that had not pyrogenicity, acute and chronic toxicity, allergenicity and immunotoxicity.

作者简介

N. Mikhailova

The Mechnikov Research Institute for Vaccines and Sera

编辑信件的主要联系方式.
Email: alex-k-1973@yandex.ru

D. Sc., Head of the Laboratory of the protective antigens,

Moscow

俄罗斯联邦

A. Kaloshin

The Mechnikov Research Institute for Vaccines and Sera

Email: fake@neicon.ru

PhD, Leading researcher of Laboratory of the protective antigens,

Moscow

俄罗斯联邦

E. Zimina

The Mechnikov Research Institute for Vaccines and Sera

Email: fake@neicon.ru

Researcher of Laboratory of the protective antigens,

Moscow

俄罗斯联邦

E. Kalinichenko

The Mechnikov Research Institute for Vaccines and Sera

Email: fake@neicon.ru

Aspirant,

Moscow

俄罗斯联邦

A. Soldatenkova

The Mechnikov Research Institute for Vaccines and Sera

Email: fake@neicon.ru

PhD, Senior research of Laboratory of the protective antigens,

Moscow

俄罗斯联邦

N. Plekhanova

The Volgograd Antiplague Research Institute of Rospotrebnadzor

Email: fake@neicon.ru

PhD, Head of the Laboratory of the experimental biomodels,

Volgograd

俄罗斯联邦

L. Victorov

The Volgograd Antiplague Research Institute of Rospotrebnadzor

Email: fake@neicon.ru

D. Sc., Head of the temporary creative team,

Volgograd

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参考

  1. Лазарева А. В., Чеботарь И. В., Крыжановская О. А., Чеботарь В. И., Маянский Н. А. Pseudomonas aeruginosa патогенность, патогенез и патология. Клиническая микробиология и антимикробная химиотерапия. 2015, 17(3):170–186.
  2. Doring G. and Pier G. B. Vaccines and immunotherapy against Pseudomonas aeruginosa. Vaccine, 2008, 6(8):1011–1024.
  3. Калошин А. А., Солдатенкова А. В., Леонова Е. И., Михайлова Н. А. Получение рекомбинантного гибридного белка OprF-aTox Pseudomonas aeruginosa и исследование его протективных свойств. Российский иммунологический журнал. 2015, 9(2): 490–491.

版权所有 © Mikhailova N.A., Kaloshin A.A., Zimina E.M., Kalinichenko E.O., Soldatenkova A.V., Plekhanova N.G., Victorov L.V., 2019

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