POLYMORPHISM OF ENZYMES OF BIOTRANSFORMATION OF XENOBIOTICS (GLUTATHIONE S-TRANSFERASES M1, T1, P1) IN PATIENTS WITH A COMBINATION OF ATOPIC DERMATITIS AND BRONCHIAL ASTHMA
- 作者: Molokova A.1
-
隶属关系:
- Novosibirsk state medical University
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 417-419
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/120233
- DOI: https://doi.org/10.31857/S102872210006916-2
- ID: 120233
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详细
The study of polymorphism of glutathione S-transferases M1, T1, P1 in children with allergic diseases showed a predominance of mutant enzyme genotypes in severe atopic dermatitis and asthma. Genotypes GSTM1«-», GSTT1«-» are signifi cant for the early formation of atopic dermatitis and bronchial asthma. Predisposition to combined atopy was registered for haplotypes M1«+»/T1«-»/P1ile105/Ile105 (OR=4.92; 95% CI 0.67–36.53) (р<0,05).
作者简介
A. Molokova
Novosibirsk state medical University
编辑信件的主要联系方式.
Email: fake@neicon.ru
PhD, Department of Pediatrics,
Novosibirsk
俄罗斯联邦参考
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- Zhong S., Wyllie A. H., Barnes D. Relationship between the GSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer. Carcinogenesis. 1993; 14, 1821–1824.
- Pemble S., Schroeder K. R., Spencer S. R. Human glutathione S-transferase Theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism. Biochem. J. 1994; 300, Pt. 1, 271–276.
