IMMUNE STATUS IN ACUTE OBSTRUCTIVE AND NONOBSTRUCTIVE PYELONEPHRITIS
- 作者: Shatokhin M.1,2, Mavrin M.2, Ragulina V.3, Khorlyakov K.3
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隶属关系:
- Russian Medical Academy of Postgraduate Education of Ministry of Health of the Russian Federation
- Urological Center “Scientific Clinical Center OJSC Russian Railways”
- Kursk State Medical University
- 期: 卷 22, 编号 2-2 (2019)
- 页面: 975-977
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/120120
- DOI: https://doi.org/10.31857/S102872210006499-3
- ID: 120120
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The patients with a diagnosis of acute non-obstructive (ANOP) and obstructive pyelonephritis (AOP) (31 and 30 patients respectively) were under observation during treatment at the urological center of the National Healthcare Institution Scientifi c Clinical Center of Russian Railways. The levels of cytokines, complement components and their inhibitors in plasma and the first portion of morning urine, phagocytic and oxygen-dependent activity of circulating blood neutrophils were determined. At the systemic level, in patients with ANOP, to a greater extent in AOP, an increase in the concentration of pro-inflammatory cytokines (TNFα, IL-6, IL-8 and IFNγ), IFNα, IL-4 and IL-10, components of the C3 and C5a compliment was established, a decrease in the level of IL-1RA and a regulator of the complement factor H system, a decrease in the activity and intensity of phagocytosis of peripheral blood neutrophils with an increase in the activity of oxygen-dependent systems were also revealed. Before treatment at the local level (in the urine) in patients with ANOP, an increase in the concentration of all studied cytokines, except IL-4, components C3 and C5, and a decrease in IL-1RA was established. In AOP, changes were more pronounced, with the exception of a reduced level of factor H and sIgA.
作者简介
M. Shatokhin
Russian Medical Academy of Postgraduate Education of Ministry of Health of the Russian Federation;Urological Center “Scientific Clinical Center OJSC Russian Railways”
编辑信件的主要联系方式.
Email: sh.77@mail.ru
Doctor of Medical Sciences, Associate Professor, Professor of the Department of Endoscopic Urology,
Moscow
俄罗斯联邦M. Mavrin
Urological Center “Scientific Clinical Center OJSC Russian Railways”
Email: fake@neicon.ru
Ph.D., urologist,
Moscow
俄罗斯联邦V. Ragulina
Kursk State Medical University
Email: fake@neicon.ru
PdH, assistant of professor,
Kursk
俄罗斯联邦K. Khorlyakov
Kursk State Medical University
Email: fake@neicon.ru
Postgraduate Student, Department of Management and Economics of Pharmacy,
Kursk
俄罗斯联邦参考
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