EFFECTS OF ACUTE COLD STESS ON IFNγ AND IL-12 PRODUCTION BY MICE SPLENOCYTES
- 作者: Sharav’eva I.1, Tendryakova S.1,2
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隶属关系:
- Institute of Ecology and Genetics of Microorganisms, UB RAS
- Perm State University
- 期: 卷 22, 编号 2-2 (2019)
- 页面: 972-974
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/120101
- DOI: https://doi.org/10.31857/S102872210006500-5
- ID: 120101
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全文:
详细
The effect of cold stress on the production of reactive oxygen species (ROS) and IFN-γ and IL-12 was studied 6 hours after the end of stress. It was established that acute cold stress (–20 °C for 60 min) led to increased spontaneous and zymosan-stimulated production of ROS by mouse peritoneal cavity cells 6 hours after the end of stress exposure. In similar experimental conditions, the levels of interferon-γ in spontaneous splenocytes mice increased, while in stimulated mice decreased.
作者简介
I. Sharav’eva
Institute of Ecology and Genetics of Microorganisms, UB RAS
编辑信件的主要联系方式.
Email: irin.sh@gmail.com
PhD, recercher of the laboratory of biochemistry of development of microorganisms,
Perm
俄罗斯联邦S. Tendryakova
Institute of Ecology and Genetics of Microorganisms, UB RAS;Perm State University
Email: fake@neicon.ru
PhD, senior recercher of the laboratory of ecological immunology;
docent Department of microbiology and immunology,
Perm
俄罗斯联邦参考
- DhaBhar F. S. The short-term stress response – Mother nature’s mechanism for enhancing protection and performance under conditions of threat, challenge, and opportunity. Frontiers in Neuroendocrinology. 2018, 49, 175–192.
- Sesti-Costa R., Ignacchiti M. D., Chedraoui-Silva S. Marchi L. F., Mantovani B. Chronic cold stress in mice induces a regulatory phenotype in macrophages: correlation with increased 11β-hydroxysteroid dehydrogenase expression. Brain Behav Immun. 2012, 26, 50–60.
- Zhu G. F., Chancellor-Freeland C., Berman A. S., Leeman S. E., Beller D. I., Black P. H. Endogenous substance P mediates cold water stress-induced increase in interleukin-6 secretion from peritoneal macrophages. 1996, J. Neurosci., 16, 3745–3752.
- Гейн С. В., Шаравьева И. Л. Влияние холодового стресса на функциональную активность перитонеальных макрофагов мыши в условиях блокады опиатных рецепторов. 2016, Российский физиологический журнал им. И. М. Сеченова, 2, 188–194.
