THE ROLE OF THE ENDOGENOUS OPIOID SYSTEM IN THE REGULATION OF ANTIBODY GENESIS DURING CHRONIC COLD STRESS

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It was established that under conditions of chronic cold stress in mice, a decrease in the absolute and relative amount of antibody-forming cells in the spleen was observed. The blockade of opiate receptors led to the abolition of oppression.

作者简介

I. Sharav’eva

Institute of Ecology and Genetics of Microorganisms, UB RAS

编辑信件的主要联系方式.
Email: irin.sh@gmail.com

PhD, recercher of the laboratory of biochemistry of development of microorganisms,

Perm

俄罗斯联邦

S. Gein

Institute of Ecology and Genetics of Microorganisms, UB RAS;
Perm State University

Email: fake@neicon.ru

doctor of medicine deputy director for research;

professor Department of microbiology and immunology,

Perm 

俄罗斯联邦

参考

  1. Vuong C., Van Uum S. H., O’Dell L. E., Lutfy K., Friedman T. C. The effects of opioids and opioid analogs on animal and human endocrine systems. Endocr Rev., 2010, 31(1), 98–132.
  2. Toubia T., Khalife T. The Endogenous opioid system: role and dysfunction caused by opioid therapy. Clin Obstet Gynecol., 2019, 62, 3–10.
  3. Kido K., Shindo Y., Toda S., Masaki E. Expression of β-endorphin in peripheral tissues after systemic administration of lipopolysaccharide as a model of endotoxic shock in mice. Ann Endocrinol, 2018, 18, 30095–7.
  4. Гейн С. В., Шаравьева И. Л. Влияние блокады опиатных рецепторов на антителогенез и пролиферативный ответ спленоцитов при стрессе. Экспериментальная и клиническая фармакология, 2013, 1, 30–34.
  5. Jerne N. K., Nordin A. A. Plaque formation in agar by single antibody-producing cells. Science, 1963, 140, 405.

版权所有 © Sharav’eva I.L., Gein S.V., 2019

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