SERUM CONTENT OF CYTOKINES REGULATING PROLIFERATION AND DIFFERENTION OF LYMPHOCYTES IN HYPERTENSIVE DISORDERS IN PREGNANT WOMEN

Relative and absolute lymphocyte amounts in the clinical (or common) blood analysis, serum levels of IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12p70, IL-15, IL-17А were investigated in pregnant women with chronic arterial hypertension, preeclampsia, and with preeclampsia on the background of chronic arterial hypertension as well as uncomplicated pregnancy (control). In all groups of women with hypertensive disorders there was a decrease in the level of lymphocytes and IL-2 and IL-15 in the blood. In contrast to the control, preeclampsia increased the contents of IL-5 and IL-6. Besides, severe preeclampsia increased the level of IL-4, IL-9, IL-17A, with chronic arterial hypertension IL-12p70. Thus, in hypertensive disorders in pregnant women, the production of cytokines regulating the proliferation of lymphocytes decreases. However, in preeclampsia, the contents of cytokines, which determine the maturation and diff erentiation of eff ector cells, increases.