The role of TCR-activation in the formation of small subpopulations of T helpers
- 作者: Timganova V.1, Zamorina S.1, Bochkova M.1, Khramtsov P.1, Raev M.1
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隶属关系:
- Institute of Ecology and Genetics of Microorganisms UB RAS
- 期: 卷 21, 编号 3 (2018)
- 页面: 449-453
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/119943
- DOI: https://doi.org/10.31857/S102872210002426-3
- ID: 119943
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详细
The role of the independent eff ect of TCR-activation in the formation of small subpopulations of T-helpers (Treg, TCM, TEM, TEMRA) was studied. It was shown that under the conditions of TCR activation, cells were redistributed in favor of eff ector subpopulations (TEM, TEMRA), while the number of naive T cells and TCM decreased. What about Treg, it was demonstrated that TCR-activation of cells resulted in increased intracellular expression of FOXP3, HELIOS and CTLA-4. In general, the presence of the TCR-activator leads to an increase in the number of eff ector T-helpers, which is accompanied by a simultaneous increase in the level of suppressive Treg.
作者简介
Valeriya Timganova
Institute of Ecology and Genetics of Microorganisms UB RAS
编辑信件的主要联系方式.
Email: noemail@neicon.ru
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Svetlana Zamorina
Institute of Ecology and Genetics of Microorganisms UB RAS
Email: noemail@neicon.ru
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Maria Bochkova
Institute of Ecology and Genetics of Microorganisms UB RAS
Email: noemail@neicon.ru
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Pavel Khramtsov
Institute of Ecology and Genetics of Microorganisms UB RAS
Email: noemail@neicon.ru
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M. Raev
Institute of Ecology and Genetics of Microorganisms UB RAS
Email: noemail@neicon.ru
俄罗斯联邦
参考
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