POPULATION COMPOSITION OF NEUTROPHILS IN THE TUBERCULOUS PROCESS

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Neutrophils are the first line of defense against infectious diseases. The contribution of neutrophils to the pathogenesis of tuberculosis is controversial and not fully understood. In this study, we analyzed the heterogeneity of neutrophil populations in patients with tuberculosis and control subjects. In patients with tuberculosis, there is an increase in the number of low-density neutrophils compared with control subjects. We have found that the low-density neutrophil population is heterogeneous and contains a subpopulation of activated cells.

作者简介

Y. Serdyuk

Сentral tuberculosis research institute

Email: yv_serdyk@mail.ru

PhD student, Junior Staff Researcher Laboratory of biotechnology,

Chelyabinsk

俄罗斯联邦

T. Nenasheva

Сentral tuberculosis research institute

Email: fake@neicon.ru

PhD, Senior Staff Researcher Laboratory of biotechnology,

Chelyabinsk

俄罗斯联邦

I. Nikitina

Сentral tuberculosis research institute

Email: fake@neicon.ru

PhD, Senior Staff Researcher Laboratory of biotechnology,

Chelyabinsk

俄罗斯联邦

N. Karpina

Сentral tuberculosis research institute

Email: fake@neicon.ru

Doctor of Medical Sc., Head of the Consultative department,

Chelyabinsk

俄罗斯联邦

I. Lyadova

Сentral tuberculosis research institute

编辑信件的主要联系方式.
Email: fake@neicon.ru

Doctor of Medical Sc., Head of the Laboratory of biotechnology,

Chelyabinsk

俄罗斯联邦

参考

  1. Almeida F. M., Ventura T. L., Amaral E. P., Ribeiro S. C., Calixto S.D., Manhães M. R., Rezende A. L., Souzal G. S., et al. (2017).“Hypervirulent Mycobacterium tuberculosis strain triggers necrotic lung pathology associated with enhanced recruitment of neutrophils in resistant C57BL/6 mice”. PloS one, 12(3): e0173715
  2. Singhal S., Bhojnagarwala P. S., O’Brien S., Moon E. K., Garfall A. L., Rao A. S., Quatromoni J. G., Stephen T. L., Litzky L., Deshpande C., et al. (2016). “Origin and role of a subset of tumor-associated neutrophils with antigen-presenting cell features in early-stage human lung cancer”.Cancer Cell, 30(1):120–135
  3. Tsiganov E. N., Verbina E. M., Radaeva T. V., Sosunov V. V., Kosmiadi G. A., Nikitina I. Y. and Lyadova I. V., (2014). “Gr-1dimCD11b+ immature myeloidderived suppressor cells but not neutrophils are markers of lethal tuberculosis infection in mice”. TheJournal of Immunology, 192(10:4718–4727.
  4. Lyadova I. V., (2017). “Neutrophils in Tuberculosis: Heterogeneity Shapes the Way?” Mediators of Inflammation, 2017:8619307
  5. Deng Y., Ye J., Luo Q., Huang Z., Peng Y., Xiong G., et al. (2016). “Low-density granulocytes are elevated in mycobacterial infection and associated with the severity of tuberculosis”. PloS one, 11(4): e0153567.

版权所有 © Serdyuk Y.V., Nenasheva T.A., Nikitina I.Y., Karpina N.L., Lyadova I.V., 2019

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此作品已接受知识共享署名 4.0国际许可协议的许可
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