CD39 AND CD73 EXPRESSION IN INTERSTITIAL CELLS OF CALCIFIED AORTIC STENOSIS

A. S. Golovkin; Головкин А. С.; E. V. Zhiduleva; Жидулева Е. В.; A. A. Shishkova; Шишкова А. А.; D. S. Semenova; Семенова Д. С.; O. M. Moiseeva; Моисеева О. М.; A. B. Malashicheva; Малашичева А. Б.

CD39 AND CD73 EXPRESSION IN INTERSTITIAL CELLS OF CALCIFIED AORTIC STENOSIS

作者: Golovkin A.¹, Zhiduleva E.¹, Shishkova A.¹, Semenova D.¹, Moiseeva O.¹, Malashicheva A.¹
隶属关系:
1. Federal Almazov Medical Research Centre
期: 卷 20, 编号 2 (2017)
页面: 287-289
栏目: Articles
URL: https://journals.rcsi.science/1028-7221/article/view/119903
ID: 119903

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Investigation of CD39 and CD73 expression on interstitial cells of calcified aortic valves of 31 patients was performed. Not significant increase (p=0,45) of CD39^-CD73⁺ in cells from tricuspid aortic valves (TAV) comparing with bicuspid valves (BAV) was shown. Only from female patient's valves the difference became significant (BAV - 23,67 (19,43;29,80)%; TAV - 59,34 (49,17;69,55)% (p=0,002)). These data proves the hypotheses of purinergic signaling involvement in calcification suggesting that it is sex related process.

关键词

кальцинированный стеноз аортального клапана, интерстициальные клетки, пуринергическая регуляция, calcified aortic stenosis, interstitial cells, purinergic regulation

参考

Головкин А. С., Кудрявцев И. В., Серебрякова М. К. и др. Кальциноз аортального клапана: субпопуляционный состав циркулирующих Т-клеток и пуринергическая регуляция. Российский иммунологический журнал. 2016; Т10(19) № 2(1):189-191.
Leopold J A. Cellular mechanisms of aortic valve calcification. Circ Cardiovasc Interv. 2012; 5(4): 605-614.
Fish R. S., Klootwijk E., Tam F. W. K., et al. ATP and arterial calcification. Eur J Clin Invest. 2013;43:405-412.
Kaniewska E., Sielicka A., Sarathchandra P., et al. Immunohistochemical and Functional Analysis of Ectonucleoside Triphosphate Diphosphohydro-lase 1 (CD39) and Ecto-5'-Nucleotidase (CD73) in Pig Aortic Valves. Nucleosides, Nucleotides and Nucleic Acids. 2014;33(4-6):305-312.
Simard L., Cote N., Dagenais F., et al. Sex-Related Discordance Between Aortic Valve Calcification and Hemodynamic Severity of Aortic Stenosis: Is Valvular Fibrosis the Explanation? Circ Res. 2017; 120:681-691.

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CD39 AND CD73 EXPRESSION IN INTERSTITIAL CELLS OF CALCIFIED AORTIC STENOSIS

全文:

详细

关键词

作者简介

A. Golovkin

E. Zhiduleva

A. Shishkova

D. Semenova

O. Moiseeva

A. Malashicheva

参考